Zobrazeno 1 - 10
of 2 536
pro vyhledávání: '"single domain antibody"'
Autor:
Amirhosein Maali, Shahriyar Abdoli, Mahdi Habibi-Anbouhi, Ahmad Noei, Maryam Kadkhodazadeh, Mahdieh Motamedirad, Arash Arashkia, Zahra Sharifzadeh
Publikováno v:
Cell Journal, Vol 26, Iss 8, Pp 487-495 (2024)
Objective: CD22, as a surface protein of B cells, is used in the diagnosis and target-specific immunotherapy of B-cellmalignancies. SpyTag and SpyCatcher, on the other hand, are two covalently coupled proteins capable of developinga bi- or multi-spec
Externí odkaz:
https://doaj.org/article/ea88165a54bb43b9b785f225dccaeb17
Autor:
Faith Njeru, Olivier Zwaenepoel, Geert Haesaert, Gerald Misinzo, Kris De Jonghe, Jan Gettemans
Publikováno v:
FEBS Open Bio, Vol 14, Iss 10, Pp 1746-1757 (2024)
Maize lethal necrosis (MLN) is a maize disease caused by the maize chlorotic mottle virus (MCMV), a potyvirus which causes yield losses of 30–100%. The present study aimed to isolate nanobodies against the MCMV coat protein (CP) for the diagnosis o
Externí odkaz:
https://doaj.org/article/5793225ef1094772b0488fe26004168c
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2854-2868 (2024)
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies. These sdAbs have many superior physicochemic
Externí odkaz:
https://doaj.org/article/9520c9a554d343f3aadcc97206844ed8
Autor:
Ling Wang, Ran Luo, Weilang Zhang, Hanyu Jiang, Yongkang Yu, Wenhu Zhou, Fan Zhang, Jian Ma, Lin Mei
Publikováno v:
Smart Materials in Medicine, Vol 5, Iss 4, Pp 501-513 (2024)
Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These feat
Externí odkaz:
https://doaj.org/article/46f53d81aad441afa8025d01061b7619
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Using conventional immunoglobulin G (IgG) molecules as therapeutic agents presents several well-known disadvantages owing to their large size and structural complexity, negatively impacting development and production efficiency. Single-domai
Externí odkaz:
https://doaj.org/article/d86067ade20f4a04a6a1aa6bb6b3d357
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionVHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional antibodies because of their smaller size, comparable binding affinity and biophysical properties. MethodIn this study, we systematically analyzed V
Externí odkaz:
https://doaj.org/article/1f8529b9ff544d39895d20d7960b777e
Autor:
Lisa A. King, Milon de Jong, Myrthe Veth, David Lutje Hulsik, Parsa Yousefi, Victoria Iglesias-Guimarais, Pauline M. van Helden, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundVγ9Vδ2 T-cells are antitumor immune effector cells that can detect metabolic dysregulation in cancer cells through phosphoantigen-induced conformational changes in the butyrophilin (BTN) 2A1/3A1 complex. In order to clinically exploit the
Externí odkaz:
https://doaj.org/article/3eb04d8fffbe403ba273566ef54bbcbc
Autor:
Behnam Hasannejad-Asl, Hassan Hashemzadeh, Farkhondeh Pooresmaeil, Mehran Dabiri, Mohammad-Reza Pooresmaeil, Davoud Ahmadvand, Arshad Hosseini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
IntroductionDuring the last decade, there has been a significant rise in the use of therapeutic antibodies or passive immunotherapy for treating various conditions like inflammation and cancer. However, these proteins face challenges reaching the bra
Externí odkaz:
https://doaj.org/article/5b8d13ba525b4be5842b0305ec777ae6
Autor:
Qian Yang, Mengru Yan, Juan Lin, Yongkang Lu, Shuang Lin, Zhong Li, He Wang, Juhua Yang, Nanwen Zhang, Xiaole Chen
Publikováno v:
PeerJ, Vol 12, p e17846 (2024)
The coronavirus disease 2019 (COVID-19) pandemic, which caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lead to a crisis with devastating disasters to global public economy and health. Several studies suggest that the SARS-CoV
Externí odkaz:
https://doaj.org/article/4fce6df326894da5afb339aea55d3666
Autor:
Ellen R. Goldman, Victor A. Sugiharto, Lisa C. Shriver-Lake, Andrew M. Garcia, Shuenn-Jue Wu, Sarah A. Jenkins, Hua-Wei Chen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Within the past decade, single domain antibodies (sdAbs) have been recognized as unique affinity binding reagents that can be tailored for performance in a variety of immunoassay formats. Luminex MagPlex color-coded magnetic microspheres provide a hi
Externí odkaz:
https://doaj.org/article/08e92e92286545abbc90ffed73f3b86e