Zobrazeno 1 - 10
of 555
pro vyhledávání: '"single cell RNA sequencing (scRNA)"'
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-17 (2024)
Abstract This study addresses the challenges in the early diagnosis of deep infiltrating endometriosis (DIE) by exploring the potential role of the deubiquitinating enzyme USP14. By analyzing the GSE141549 dataset from the Gene Expression Omnibus (GE
Externí odkaz:
https://doaj.org/article/d65e413f734f492dad7f62387439997c
Autor:
Yuan‐Ping Yang, Zhi‐Guang Huang, Jia‐Yuan Luo, Juan He, Lin Shi, Gang Chen, Si‐Yuan Chen, Yu‐Wen Deng, Yi‐Jia Yang, Yi‐Jun Tang, Yu‐Yan Pang
Publikováno v:
IET Systems Biology, Vol 18, Iss 5, Pp 183-198 (2024)
Abstract Synaptojanin 2 (SYNJ2) has crucial role in various tumors, but its role in papillary thyroid carcinoma (PTC) remains unexplored. This study first detected SYNJ2 protein expression in PTC using immunohistochemistry method and further assessed
Externí odkaz:
https://doaj.org/article/8ff252af1f3e40c39bfc48dacd0ab758
Autor:
Hao Jiang, Biao Gao, Zihe Meng, Yafei Wang, Tianyu Jiao, Junfeng Li, Xuerui Li, Yinbiao Cao, Xianzhou Zhang, Chonghui Li, Shichun Lu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract This study aims to investigate the interplay between tumor-associated endothelial cells (TECs) and immune cells within the tumor microenvironment (TME) and its impact on tumor prognosis. We conducted single-cell RNA sequencing (scRNA-seq) of
Externí odkaz:
https://doaj.org/article/e6a5f4bd94c440f2b92902d421d1c35c
Autor:
Yujing Sun, Zhenhua Zhang, Qincheng Qiao, Ying Zou, Lina Wang, Tixiao Wang, Bo Lou, Guosheng Li, Miao Xu, Yanxiang Wang, Zhenhong Zhang, Xinguo Hou, Li Chen, Ruxing Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral b
Externí odkaz:
https://doaj.org/article/8ea964cfb0db40a2882660eb63ef2a0b
Autor:
Yingchun Zheng, Ting Lu, Leitao Zhang, Zhongzhi Gan, Aoxi Li, Chuandong He, Fei He, Sha He, Jian Zhang, Fu Xiong
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The molecular mechanisms and signaling pathways involved in tooth morphogenesis have been the research focus in the fields of tooth and bone development. However, the cell population in molars at the late bell stage and the mechan
Externí odkaz:
https://doaj.org/article/00ba2e3c7982452b81d7e1c5dc358082
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Messenger RNA splicing and degradation are critical for gene expression regulation, the abnormality of which leads to diseases. Previous methods for estimating kinetic rates have limitations, assuming uniform rates across cells. DeepKINET is
Externí odkaz:
https://doaj.org/article/961a13bb7b534e94b277f4ba4abf350f
Autor:
Katelyn Del Toro, Yamhilette Licon-Munoz, William Crabtree, Tristan Oper, Christine Robbins, William C. Hines
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionEffective treatment of breast cancer remains a formidable challenge, partly due to our limited understanding of the complex microenvironmental factors that contribute to disease pathology. Among these factors are tissue-resident perivascu
Externí odkaz:
https://doaj.org/article/c0645c076ab743c6a88b6de4217ba8d0
Autor:
Xinlu Li, XiaoJing Dong, Wen Zhang, Zhizhou Shi, Zhongjian Liu, Yalian Sa, Li Li, Ninghua Ni, Yan Mei
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Diabetic retinopathy (DR) is a leading global cause of vision impairment, with its prevalence increasing alongside the rising rates of diabetes mellitus (DM). Despite the retina’s complex structure, the underlying pathology of DR remains incomplete
Externí odkaz:
https://doaj.org/article/1e7b20af7ef74c7d96275ac4fdea1743
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundColorectal cancer (CRC) is a leading cause of cancer-related deaths globally. The heterogeneity of the tumor microenvironment significantly influences patient prognosis, while the diversity of tumor cells shapes its unique characteristics.
Externí odkaz:
https://doaj.org/article/24b8005060f94fa782b26d9a8b4e5168
Autor:
Raneesh Ramarapu, Judit M. Wulcan, Haiyang Chang, Peter F. Moore, William Vernau, Stefan M. Keller
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe domestic cat (Felis catus) is a valued companion animal and a model for virally induced cancers and immunodeficiencies. However, species-specific limitations such as a scarcity of immune cell markers constrain our ability to resolve i
Externí odkaz:
https://doaj.org/article/f0b91dfbbe624e66a4b88a1a10bd40f1