Zobrazeno 1 - 10
of 12 087
pro vyhledávání: '"single cell RNA sequencing"'
Autor:
Chenhao Shi, Yonggang Fan, Xiusheng Huang, Mingzhe Fan, Lantian Zhao, Huafeng Zhang, Shuangfei Ni
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Low back pain (LBP) is largely attributed to intervertebral disc degeneration (IVDD), of which the endplate changes are an important component. However, the alterations in cell fate and properties within the endplates during degeneration rem
Externí odkaz:
https://doaj.org/article/fa4e03300ed24adea12a3c6ab5665bed
Autor:
Zhuman Wen, Abduxukur Ablimit
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract It is estimated that there are 544.9 million people suffering from chronic respiratory diseases in the world, which is the third largest chronic disease. Although there are various clinical treatment methods, there is no specific drug for ch
Externí odkaz:
https://doaj.org/article/6338a9a63acb450cb15b9822cd0ad849
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Lower-grade gliomas (LGGs), despite their generally indolent clinical course, are characterized by invasive growth patterns and genetic heterogeneity, which can lead to malignant transformation, underscoring the need for improved prognostic
Externí odkaz:
https://doaj.org/article/dfb49c875bfd4a5f80d74d3ad0f13905
Expression and biological significance of topoisomerase II α (TOP2A) in oral squamous cell carcinoma
Autor:
Xujie Cheng, Yuxing Wei, Limei Deng, Hao Dong, Huiping Wei, Cheng Xie, Yangjuan Tuo, Meiyu Chen, Hao Qin, Yong Cao
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background Topoisomerase II α(TOP2A) is usually highly expressed in rapidly proliferating cells, and its expression is regulated by cell cycle. The relationship between TOP2A and oral squamous cell carcinoma (OSCC) needs further study. Meth
Externí odkaz:
https://doaj.org/article/b3d280d0eb894a7eb1102f307b6316e1
Autor:
Quanlei Liu, Chunhao Shen, Yang Dai, Ting Tang, Changkai Hou, Hongyi Yang, Yihe Wang, Jinkun Xu, Yongchang Lu, Yunming Wang, Yongzhi Shan, Penghu Wei, Guoguang Zhao
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Background Temporal lobe epilepsy (TLE) is among the most common types of epilepsy and often leads to cognitive, emotional, and psychiatric issues due to the frequent seizures. A notable pathological change related to TLE is hippocampal scle
Externí odkaz:
https://doaj.org/article/f43d3a21a3bb48b8b83c1a93dcccf0d5
Autor:
Wen Tong, Tianze Wang, Yi Bai, Xingpeng Yang, Pinsheng Han, Liuyang Zhu, Yamin Zhang, Zhongyang Shen
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The tumor microenvironment (TME) exerts profound effects on tumor progression and therapeutic efficacy. In hepatocellular carcinoma (HCC), the TME is enriched with cancer-associated fibroblasts (CAFs), which secrete a plethora of
Externí odkaz:
https://doaj.org/article/12475b3f580e4025bd215d09e113760f
Autor:
Yingchun Zheng, Ting Lu, Leitao Zhang, Zhongzhi Gan, Aoxi Li, Chuandong He, Fei He, Sha He, Jian Zhang, Fu Xiong
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The molecular mechanisms and signaling pathways involved in tooth morphogenesis have been the research focus in the fields of tooth and bone development. However, the cell population in molars at the late bell stage and the mechan
Externí odkaz:
https://doaj.org/article/00ba2e3c7982452b81d7e1c5dc358082
Autor:
Chengniu Wang, Xiaorong Wang, Wenran Wang, Yufei Chen, Hanqing Chen, Weizhen Wang, Taowen Ye, Jin Dong, Chenliang Sun, Xiaoran Li, Chunhong Li, Jiaying Li, Yong Wang, Xingmei Feng, Hongping Ding, Dawei Xu, Jianwu Shi
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Background The cell development atlas of transition stage from late Carnegie to fetal development (7–9 weeks) remain unclear. It can be seen that the early period of human embryos (7–9 weeks) is a critical research gap. Therefore, we emp
Externí odkaz:
https://doaj.org/article/24b4cac8d8c14148a086d8722d16ad4c
Autor:
Huang-Chun Lien, Hui-Chieh Yu, Wen-Hsuan Yu, Su-Fang Lin, Tom Wei-Wu Chen, I-Chun Chen, Li-Ping Hsiao, Ling-Chun Yeh, Yu-Chia Li, Chiao Lo, Yen-Shen Lu
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract Background Although tumor cells undergoing epithelial–mesenchymal transition (EMT) typically exhibit spindle morphology in experimental models, such histomorphological evidence of EMT has predominantly been observed in rare primary spindle
Externí odkaz:
https://doaj.org/article/9f78f937e516410bb7a31f55e1254237
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Messenger RNA splicing and degradation are critical for gene expression regulation, the abnormality of which leads to diseases. Previous methods for estimating kinetic rates have limitations, assuming uniform rates across cells. DeepKINET is
Externí odkaz:
https://doaj.org/article/961a13bb7b534e94b277f4ba4abf350f