Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors

Autor: Junjun Qiu, Tingting Ren, Qinqin Liu, Qian Jiang, Tong Wu, Leong Chi Cheng, Wenqing Yan, Xinyu Qu, Xiao Han, Keqin Hua

Publikováno v: Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)

Abstract High‐grade serous tubo‐ovarian cancer (HGSTOC) is an aggressive gynecological malignancy including homologous recombination deficient (HRD) and homologous recombination proficient (HRP) groups. Despite the therapeutic potential of poly (

Externí odkaz: https://doaj.org/article/6a60b6be7742423887fe44ba123b0664

Divergent outcomes of anti-PD-L1 treatment coupled with host-intrinsic differences in TCR repertoire and distinct T cell activation states in responding versus non-responding tumors

Autor: Jessy John, Rachel A. Woolaver, Vince Popolizio, Samantha M. Y. Chen, Huaibin Ge, Alexandra L. Krinsky, Monika Vashisht, Yonatan Kramer, Zhangguo Chen, Jing H. Wang

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Differential responses to immune checkpoint inhibitors (ICI) may be attributed to tumor-intrinsic factors or environmental cues; however, these mechanisms cannot fully explain the variable ICI responses in different individuals. Here, we investigate

Externí odkaz: https://doaj.org/article/f5b78caa49bf4ebaae7aefd9334011c3

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The Role of Single-Cell Profiling and Deep Immunophenotyping in Understanding Immune Therapy Cardiotoxicity.

Autor: Huang YV; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.; Cornell University, Ithaca, New York, USA., Waliany S; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Lee D; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA., Galdos FX; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA., Witteles RM; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Neal JW; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.; Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.; Stanford Cancer Institute, Stanford University, Stanford, California, USA., Fan AC; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.; Division of Oncology, Stanford University School of Medicine, Stanford, California, USA.; Stanford Cancer Institute, Stanford University, Stanford, California, USA., Maecker HT; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA., Nguyen PK; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Wu SM; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Zhu H; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.

Publikováno v: JACC. CardioOncology [JACC CardioOncol] 2022 Dec 20; Vol. 4 (5), pp. 629-634. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022).