Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers

Autor: Skrzycki Michał

Publikováno v: Open Life Sciences, Vol 16, Iss 1, Pp 1225-1239 (2021)

This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene

Externí odkaz: https://doaj.org/article/c11c3b7f13204115b98f09947c5b75dc

Safe and Efficient Sigma1 Ligand: A Potential Drug Candidate for Multiple Sclerosis

Autor: Bénédicte Oxombre, Fahima Madouri, Anne-Sophie Journé, Séverine Ravez, Eloise Woitrain, Pascal Odou, Nathalie Duhal, Sandro Ninni, David Montaigne, Nadira Delhem, Patrick Vermersch, Patricia Melnyk

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 19, p 11893 (2022)

Multiple Sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of the central nervous system (CNS). Current management strategies suppress or modulate immune function, all with consequences and known side effects. They demonstra

Externí odkaz: https://doaj.org/article/6c398fed2d04454fab0414efedc246c1

Docking, Interaction Fingerprint, and Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) of Sigma1 Receptor Ligands, Analogs of the Neuroprotective Agent RC-33

Autor: José Luis Velázquez-Libera, Giacomo Rossino, Carlos Navarro-Retamal, Simona Collina, Julio Caballero

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

The human Sigma1 receptor (S1R), which has been identified as a target with an important role in neuropsychological disorders, was first crystallized 3 years ago. Since S1R structure has no relation with another previous crystallized structures, the

Externí odkaz: https://doaj.org/article/f201896eb2b24e4ba2ad186dfb9c1cd3

Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers

Autor: Michał Skrzycki

Publikováno v: Open Life Sciences, Vol 16, Iss 1, Pp 1225-1239 (2021)
Open Life Sciences

This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bf6c991d04addbe1d171cd17aa6c70
https://doaj.org/article/c11c3b7f13204115b98f09947c5b75dc

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

Autor: Shao-Ming Wang, Hsiang-En Wu, Yuko Yasui, Michal Geva, Michael Hayden, Tangui Maurice, Mauro Cozzolino, Tsung-Ping Su

Publikováno v: Autophagy (2022).
info:cnr-pdr/source/autori:Shao-Ming Wang, Hsiang-En Wu, Yuko Yasui, Michal Geva, Michael Hayden, Tangui Maurice, Mauro Cozzolino, Tsung-Ping Su/titolo:Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1%2Fsigma-1 receptor chaperone by pridopidine/doi:/rivista:Autophagy/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume

Macroautophagy/autophagy is an essential process for cellular survival and is implicated in many diseases. A critical step in autophagy is the transport of the transcription factor TFEB from the cytosol into the nucleus, through the nuclear pore (NP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfc7f86000874fd3d4fca4263f545b3