Zobrazeno 1 - 10
of 1 933
pro vyhledávání: '"siglec"'
Autor:
Ghazaleh Eskandari-Sedighi, Madeline Crichton, Sameera Zia, Erik Gomez-Cardona, Leonardo M. Cortez, Zain H. Patel, Kei Takahashi-Yamashiro, Chris D. St. Laurent, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew S. Macauley
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-27 (2024)
Abstract Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility
Externí odkaz:
https://doaj.org/article/e2bd71e630ca42e2903e16f780fc40b0
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Long non-coding RNAs (lncRNAs) and Sialic acid-binding immunoglobulin-type lectin (SIGLEC) family members play an important role in proliferation, apoptosis, immune-cell activation and tumor development. However, the relationships of SIGLEC
Externí odkaz:
https://doaj.org/article/0a087b6b607c4cba84f4b6ff633d8b3d
Autor:
Yingyan Yu, Wenjie Peng
Publikováno v:
Cancer Biology & Medicine, Vol 20, Iss 5, Pp 369-384 (2023)
Malignant tumors are complex structures composed of cancer cells and tumor microenvironmental cells. In this complex structure, cells cross-talk and interact, thus jointly promoting cancer development and metastasis. Recently, immunoregulatory molecu
Externí odkaz:
https://doaj.org/article/22b5ba4122704292990679abaaf90e35
Autor:
Tiantian Li, Ji Yao
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundDespite the recognized roles of Sialic acid-binding Ig-like lectins (SIGLECs) in endocytosis and immune regulation across cancers, their molecular intricacies in colon adenocarcinoma (COAD) are underexplored. Meanwhile, the complicated inte
Externí odkaz:
https://doaj.org/article/4c3e937d9b454dc5b45e84977461617d
Autor:
Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Alexandre Girard, Claudia Cicala, James Arthos, John H Kehrl
Publikováno v:
eLife, Vol 12 (2024)
The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or deliver it directly via inoculation to engender a protective immune response. The t
Externí odkaz:
https://doaj.org/article/253ce2a9a2df464f99f6267ec26b993b
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the central nervous system (CNS). Sialic acid-binding immunoglobulin-li
Externí odkaz:
https://doaj.org/article/5b5dfb20ce8a4357afcc6a3d275440e9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/e74bc128068f4f0a945c504bc7ed38f6
Publikováno v:
Frontiers in Hematology, Vol 3 (2024)
There is growing recognition of the importance of sialylation as a critical post translational modification in cancer. In this article we review the role of increased cell surface sialylation (hypersialylation) in Multiple Myeloma as it relates to ce
Externí odkaz:
https://doaj.org/article/f586f68ca55c465981fdf07ac019f9a2
Autor:
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Publikováno v:
Translational Oncology, Vol 40, Iss , Pp 101840- (2024)
Osteosarcoma is the most common primary malignant bone tumor with elevated disability and mortality rates in children and adolescents and the therapeutic effect for osteosarcoma has remained stagnant in the past 30 years. Emerging evidence has shown
Externí odkaz:
https://doaj.org/article/a07fa1553b92478992da1db865e2595a
Autor:
James Ahodantin, Jiapeng Wu, Masaya Funaki, Jair Flores, Xu Wang, Pan Zheng, Yang Liu, Lishan Su
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 3, Pp 101367- (2024)
Background & Aims: Siglec-H is a receptor specifically expressed in mouse plasmacytoid dendritic cells (pDCs), which functions as a negative regulator of interferon-α production and plays a critical role in pDC maturation to become antigen-presentin
Externí odkaz:
https://doaj.org/article/adb7a57e78d64745a19d4434f3c369d7