The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

Autor: Isabella Gensler, Thomas Baukrowitz, Niels Decher, Aytug K. Kiper, Phillip J. Stansfeld, Marcus Schewe, Wendy González, Diana Aser, Mauricio Bedoya, Susanne Rinné, David Ramírez, Michael F. Netter, Kirsty S Vowinkel

Publikováno v: eLife, Vol 8 (2019)

Two-pore-domain potassium (K2P) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs prefere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a22eafb9a6fc4674d02dfc4cde212fb
https://elifesciences.org/articles/39476

The molecular basis for an allosteric inhibition of K ⁺ -flux gating in K 2P channels.

Autor: Rinné S; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany., Kiper AK; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany., Vowinkel KS; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany., Ramírez D; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Talca, Chile., Schewe M; Institute of Physiology, University of Kiel, Kiel, Germany., Bedoya M; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile., Aser D; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany., Gensler I; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany., Netter MF; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany., Stansfeld PJ; Structural Bioinformatics and Computational Biochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Baukrowitz T; Institute of Physiology, University of Kiel, Kiel, Germany., Gonzalez W; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile., Decher N; Institute for Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany.

Publikováno v: ELife [Elife] 2019 Feb 26; Vol. 8. Date of Electronic Publication: 2019 Feb 26.