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Akademický článek

Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease

Autor: Jingxia Du, Hanqi Shui, Rongjun Chen, Yibo Dong, Chengyao Xiao, Yue Hu, Nai-Kei Wong

Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 8031-8052 (2024)

Neuraminidases catalyze the desialylation of cell-surface glycoconjugates and play crucial roles in the development and function of tissues and organs. In both physiological and pathophysiological contexts, neuraminidases mediate diverse biological a

Externí odkaz: https://doaj.org/article/28d55a6346104e9d8db600b3f020cea4

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Akademický článek

A comparative study of the substrate preference of the sialidases, CpNanI, HpNanH, and BbSia2 towards 2-Aminobenzamide-labeled 3′-Sialyllactose, 6′-Sialyllactose, and Sialyllacto-N-tetraose-b

Autor: Madhu Lata, T.N.C. Ramya

Publikováno v: Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101791- (2024)

Sialidases catalyze the removal of terminal sialic acids from sialylated biomolecules, and their substrate preference is frequently indicated in terms of the glycosidic linkages cleaved (α2-3, α2-6, and α2-8) without mention of the remaining sub-t

Externí odkaz: https://doaj.org/article/b9c92585b57e468c8b96166ef9a57d5c

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Akademický článek

Possible involvement of sialidase and sialyltransferase activities in a stage-dependent recycling of sialic acid in some organs of type 1 and type 2 diabetic rats

Autor: Osas Graham Erhabor, Peter Obochi, Murtala Bindawa Isah, Mohammed Aliyu Usman, Ismaila Alhaji Umar, Mthokozisi B. C. Simelane, Mohammed Nasir Shuaibu, Md. Shahidul Islam, Mohammed Auwal Ibrahim

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

BackgroundType 1 (T1D) and type 2 (T2D) diabetes lead to an aberrant metabolism of sialoglycoconjugates and elevated free serum sialic acid (FSSA) level. The present study evaluated sialidase and sialyltranferase activities in serum and some organs r

Externí odkaz: https://doaj.org/article/789d7a74de3c4f2982c36d2349c508fe

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Akademický článek

Clostridium perfringens sialidase interaction with Neu5Ac α-Gal sialic acid receptors by in-silico observation and its impact on monolayers cellular behavior structure

Autor: Ryan Septa Kurnia, Amin Soebandrio, Vivi Hardianty Harun, Christian Marco Hadi Nugroho, Desak Gede Budi Krisnamurti, Okti Nadia Poetri, Agustin Indrawati, Simson Tarigan, Ketut Karuni Nyanakumari Natih, Fera Ibrahim, Pratiwi Pudjilestari Sudarmono, Otto Sahat Martua Silaen

Publikováno v: Journal of Advanced Veterinary and Animal Research, Vol 10, Iss 4, Pp 667-676 (2023)

Objective: This study aims to evaluate the effect of Clostridium perfringens sialidase treatment on monolayer cell behavior using computational screening and an in vitro approach to demonstrate interaction between enzyme-based drugs and ligands in ho

Externí odkaz: https://doaj.org/article/baadbc3620c847c5b5ec2f95eb9e80ad

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Akademický článek

Intranasal Trans-Sialidase Vaccine Mitigates Acute and Chronic Pathology in a Preclinical Oral Chagas Disease Model

Autor: Maria Florencia Pacini, Camila Bulfoni Balbi, Brenda Dinatale, Cecilia Farré, Paula Cacik, Florencia Belén Gonzalez, Iván Marcipar, Ana Rosa Pérez

Publikováno v: Vaccines, Vol 12, Iss 10, p 1171 (2024)

Chagas disease, caused by Trypanosoma cruzi, leads to severe complications in 30% of infected individuals, including acute myocarditis and chronic fibrosing cardiomyopathy. Despite the significant burden of this disease, there is currently no license

Externí odkaz: https://doaj.org/article/38ddec70a1814372b0a9355cfb1770b1

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Akademický článek

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Akademický článek

The role of sialidases in the pathogenesis of bacterial vaginosis and their use as a promising pharmacological target in bacterial vaginosis

Autor: Liuyan Chen, Jiayue Li, Bingbing Xiao

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Bacterial vaginosis (BV) is an infection of the genital tract characterized by disturbance of the normally Lactobacilli-dominated vaginal flora due to the overgrowth of Gardnerella and other anaerobic bacteria. Gardnerella vaginalis, an anaerobic pat

Externí odkaz: https://doaj.org/article/ce91cd6cd4f2445589cba631dd0e7a2b

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Akademický článek

Structural and functional characterization of cold-active sialidase isolated from Antarctic fungus Penicillium griseofulvum P29

Autor: Aleksandar Dolashki, Radoslav Abrashev, Dimitar Kaynarov, Ekaterina Krumova, Lyudmila Velkova, Rumyana Eneva, Stefan Engibarov, Yana Gocheva, Jeny Miteva-Staleva, Vladislava Dishliyska, Boryana Spasova, Maria Angelova, Pavlina Dolashka

Publikováno v: Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101610- (2024)

The fungal strain, Penicillium griseofulvum P29, isolated from a soil sample taken from Terra Nova Bay, Antarctica, was found to be a good producer of sialidase (P29). The present study was focused on the purification and structural characterization

Externí odkaz: https://doaj.org/article/897e11fc99ad4f11b32bcd2d14843cb0

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Akademický článek

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