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Engineering approaches in siRNA delivery

Autor: Sara Cascone, Roberto Andrea Abbiati, Mario Grassi, Michela Abrami, Anna Angela Barba, Gianluca Chiarappa, Vincenzo La Carrubba, Gabriele Grassi, Giovanna Tomaiuolo, Diego Caccavo, Francesco Carfì Pavia, Davide Manca, Gaetano Lamberti, Giulio Ghersi, Valerio Brucato, Stefano Guido

Publikováno v: International journal of pharmaceutics. 525(2)

siRNAs are very potent drug molecules, able to silence genes involved in pathologies development. siRNAs have virtually an unlimited therapeutic potential, particularly for the treatment of inflammatory diseases. However, their use in clinical practi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844390d7b792ed87b1f4d7d1bbfec9b4
https://pubmed.ncbi.nlm.nih.gov/28213276

Engineering pH-Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics.

Autor: Boloix A; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain., Feiner-Gracia N; Nanoscopy for Nanomedicine Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, 08024, Spain.; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, 5612AZ, The Netherlands., Köber M; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain., Repetto J; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain., Pascarella R; Nanoscopy for Nanomedicine Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, 08024, Spain.; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, 5612AZ, The Netherlands., Soriano A; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain., Masanas M; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain., Segovia N; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain., Vargas-Nadal G; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain., Merlo-Mas J; Nanomol Technologies SL, Campus de la UAB, Bellaterra, 08193, Spain., Danino D; CryoEM Laboratory of Soft Matter, Technion - Israel Institute of Technology, Haifa, 32000, Israel.; Guangdong Technion - Israel Institute of Technology, Shantou, Guangdong Province, 515063, China., Abutbul-Ionita I; CryoEM Laboratory of Soft Matter, Technion - Israel Institute of Technology, Haifa, 32000, Israel., Foradada L; Peptomyc S.L., Vall d'Hebron Institut d'Oncologia (VHIO)- Edifici Cellex, Barcelona, 08035, Spain., Roma J; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain., Córdoba A; Nanomol Technologies SL, Campus de la UAB, Bellaterra, 08193, Spain., Sala S; Nanomol Technologies SL, Campus de la UAB, Bellaterra, 08193, Spain., de Toledo JS; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain., Gallego S; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain., Veciana J; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain., Albertazzi L; Nanoscopy for Nanomedicine Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, 08024, Spain.; Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, 5612AZ, The Netherlands., Segura MF; Laboratory of Translational Research in Childhood and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-UAB, Barcelona, 08035, Spain., Ventosa N; Molecular Nanoscience and Organic Materials (Nanomol), Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2022 Jan; Vol. 18 (3), pp. e2101959. Date of Electronic Publication: 2021 Nov 16.