Zobrazeno 1 - 10
of 253
pro vyhledávání: '"siRNA screen"'
Publikováno v:
Cells, Vol 13, Iss 7, p 577 (2024)
Hereditary spastic paraplegias (HSPs) are a heterogeneous group of mono-genetic inherited neurological disorders, whose primary manifestation is the disruption of the pyramidal system, observed as a progressive impaired gait and leg spasticity in pat
Externí odkaz:
https://doaj.org/article/481c15ea008d4d289ca6e9b1b96eb7de
Akademický článek
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Autor:
Chen-Hsuin Lee, Finn Grey
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Human Cytomegalovirus (HCMV) is a highly prevalent herpesvirus, persistently infecting between 30 and 100% of the population, depending on socio-economic status (Fields et al., 2013). HCMV remains an important clinical pathogen accounting for more th
Externí odkaz:
https://doaj.org/article/1e3465d6f478429a85fd4bcfb716bf98
Autor:
Iwona Szczerbinska, Annamaria Tessitore, Lena Kristina Hansson, Asmita Agrawal, Alejandro Ragel Lopez, Marianne Helenius, Andrzej R. Malinowski, Barak Gilboa, Maxwell A. Ruby, Ramneek Gupta, Carina Ämmälä
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 103 (2022)
Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an underlying factor in the pathophysiology of the disease. Understanding t
Externí odkaz:
https://doaj.org/article/8d9fe13e5b8444fbb608f7641527c27e
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate a healthy CNS-support
Externí odkaz:
https://doaj.org/article/592fd89fac0e4970a5a7783bf50bca8a
Autor:
Chen-Hsuin Lee, Samantha Griffiths, Paul Digard, Nhan Pham, Manfred Auer, Juergen Haas, Finn Grey
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT As obligate intracellular pathogens, viruses rely on the host cell machinery to replicate efficiently, with the host metabolism extensively manipulated for this purpose. High-throughput small interfering RNA (siRNA) screens provide a systema
Externí odkaz:
https://doaj.org/article/d5aaad040e7b479ba3c9f90dcfbf25d7
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2671-2678 (2016)
The protein product of the Homo sapiens TP53 gene is a transcription factor (p53) that regulates the expression of genes critical for the response to DNA damage and tumor suppression, including genes involved in cell cycle arrest, apoptosis, DNA repa
Externí odkaz:
https://doaj.org/article/89b57e656c54422d819d72fcf0c4fc80
Autor:
Cheng-Xu Delon Toh, Jun-Wei Chan, Zheng-Shan Chong, Hao Fei Wang, Hong Chao Guo, Sandeep Satapathy, Dongrui Ma, Germaine Yen Lin Goh, Ekta Khattar, Lin Yang, Vinay Tergaonkar, Young-Tae Chang, James J. Collins, George Q. Daley, Keng Boon Wee, Chadi A. EL Farran, Hu Li, Yoon-Pin Lim, Frederic A. Bard, Yuin-Han Loh
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2597-2607 (2016)
Incomplete knowledge of the mechanisms at work continues to hamper efforts to maximize reprogramming efficiency. Here, we present a systematic genome-wide RNAi screen to determine the global regulators during the early stages of human reprogramming.
Externí odkaz:
https://doaj.org/article/d554b35af404415ab36b81ffa2e4bf3a
Autor:
Thomas D Baird, Ken Chih-Chien Cheng, Yu-Chi Chen, Eugen Buehler, Scott E Martin, James Inglese, J Robert Hogg
Publikováno v:
eLife, Vol 7 (2018)
The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts containing premature termination codons (PTCs) and regulates expression of 5–10% of non-aberrant human mRNAs. To date, most proteins involved in NMD have been identified by
Externí odkaz:
https://doaj.org/article/7ecc3ea4baf745df9eca9cfa37e05400
Autor:
Linbo Zhao, Michael J. Imperiale
Publikováno v:
mSphere, Vol 2, Iss 4 (2017)
ABSTRACT BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection is ubiquitous in the human population, with over 80% of adults worldwide being seropositive for BKPyV. BKPyV infection is usually asymptomatic; however, BKPy
Externí odkaz:
https://doaj.org/article/fe4a3ae4a9a349739d747e73c5fa1048