Zobrazeno 1 - 10
of 53
pro vyhledávání: '"siRNA, short interfering RNA"'
Autor:
Ying Yan, Chitra Palanivel, Charles A. Enke, Geoffrey A. Talmon, Nichole D. Brandquist, Keith R. Johnson, Lepakshe S. V. Madduri, Michael J. Baine, Sumin Zhou, Michel M. Ouellette
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1192-1203 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
We have previously reported an important role of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase, in the support of critical oncogenic pathways required for oncogenesis and the malignant phenotype of pancreatic cancer. The studies in this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832db5958c0092cf4988a30bef03318
http://www.sciencedirect.com/science/article/pii/S1476558621000877
http://www.sciencedirect.com/science/article/pii/S1476558621000877
Autor:
Yu Yu, Jingying Lin, Jiantao Mai, Chen Weizhao, Ling Rongsong, Beixin Mo, Liao Lingling, Guo Xiaolong
Publikováno v:
Synthetic and Systems Biotechnology, Vol 6, Iss 4, Pp 437-445 (2021)
Synthetic and Systems Biotechnology
Synthetic and Systems Biotechnology
The invasive plant Mikania micrantha Kunth (M. micrantha) from South America poses a significant threat to the stability and biodiversity of ecosystems. However, an effective and economical method to control M. micrantha is still lacking. RNA interfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbf6cc8d2350cd4b87efed7a79b75ec
https://doi.org/10.1016/j.synbio.2021.11.005
https://doi.org/10.1016/j.synbio.2021.11.005
Autor:
Liang Han, Chen Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and severely limits brain penetration of systemically administered drugs, resulting in ineffective drug therapy of brain diseases. However, during the onset and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5b
http://www.sciencedirect.com/science/article/pii/S2211383520308522
http://www.sciencedirect.com/science/article/pii/S2211383520308522
Autor:
Kenji Izumi, Nyein Nyein Chan, Jun-ichi Tanuma, Satoshi Maruyama, Kenta Haga, Masami Kawaharada, Manabu Yamazaki, Ayako Suzuki, Toshihiko Mikami, Tadaharu Kobayashi, Emi Hoshikawa, Akinori Funayama
Publikováno v:
Translational Oncology, Vol 14, Iss 12, Pp 101236-(2021)
Translational Oncology
Translational Oncology
Highlights • TGF-β1 secreted from CAFs promote the migration and invasion of OSCC cells. • CAFs upregulate SOX9 expression of OSCC cells, possibly through inducing EMT. • The presence of CAFs is correlated with SOX9 expression in the invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37e513d06f9e4f0bfec369f2e664e8f
http://www.sciencedirect.com/science/article/pii/S193652332100228X
http://www.sciencedirect.com/science/article/pii/S193652332100228X
Autor:
Alaa A. A. Aljabali, Nitin Charbe, Poonam Negi, Nikhil D. Amnerkar, Gaurav Gupta, B. Ramesh, Meenu Metha, Hamid A. Bakshi, Dinesh Kumar Chellappan, Saurabh C. Khadse, Garima Shrivastava, Saurabh Satija, Kamal Dua, Flavia C. Zacconi, Murtaza M. Tambuwala, Rajendran Satheeshkumar
Publikováno v:
Acta Pharmaceutica Sinica. B
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2071f422f1c1f8a688b18780d3afbc9c
https://pubmed.ncbi.nlm.nih.gov/33304780
https://pubmed.ncbi.nlm.nih.gov/33304780
Autor:
Hironori Nagasaka, Ayano Inui, Satoshi Watanabe, Akinari Fukuda, Yasuhiro Hasegawa, Hisamitsu Hayashi, Kei Minowa, Takao Togawa, Hiroyuki Kusuhara, Hiroki Kondou, Koji Muroya, Kazuhiko Bessho, Sotaro Naoi, Mika Sasaki, Yu Hirose, Mureo Kasahara, Daiki Abukawa, Satoshi Nakano, Mitsuyoshi Suzuki
Publikováno v:
EBioMedicine
EBioMedicine, Vol 27, Iss C, Pp 187-199 (2018)
EBioMedicine, Vol 27, Iss C, Pp 187-199 (2018)
Progressive familial intrahepatic cholestasis type 1 (PFIC1), a rare inherited recessive disease resulting from a genetic deficiency in ATP8B1, progresses to liver failure. Because of the difficulty of discriminating PFIC1 from other subtypes of PFIC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f9fb110b31aa10ac56f655e00fc318
https://doi.org/10.1016/j.ebiom.2017.10.007
https://doi.org/10.1016/j.ebiom.2017.10.007
Autor:
Dan Xie, Wensu Wei, Zhen Li, Lijuan Jiang, Minhua Deng, Xiangdong Li, Fangjian Zhou, Pei Dong, Wenhua Lu, Zhiyong Li, Ning Wang, Zhuowei Liu, Zhen Xiang, Jian-ye Liu, Zhen-hua Liu, Chunping Yu, Kai Yao, Yulu Peng, Zhiling Zhang, Yunlin Ye
Publikováno v:
Redox Biology
Redox Biology, Vol 48, Iss, Pp 102201-(2021)
Redox Biology, Vol 48, Iss, Pp 102201-(2021)
Reactive oxygen species (ROS) which are continuously generated mainly by mitochondria, have been proved to play an important role in the stress signaling of cancer cells. Moreover, pentatricopeptide repeat (PPR) proteins have been suggested to take p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d6519110da67e6032cff8ea1984f5b
https://doi.org/10.1016/j.redox.2021.102201
https://doi.org/10.1016/j.redox.2021.102201
Publikováno v:
Redox Biology, Vol 11, Iss, Pp 254-262 (2017)
Redox Biology
REDOX BIOLOGY(11)
Redox Biology
REDOX BIOLOGY(11)
Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production. However, the molecular mechanisms regulating cancer cell death and the resistance of cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65a5ee84666c1b2e71bee510cc6398f
https://doi.org/10.1016/j.redox.2016.12.010
https://doi.org/10.1016/j.redox.2016.12.010
Autor:
Heinrich Leonhardt, Florian D. Hastert, Katrin Schmidthals, M. Cristina Cardoso, Oliver Mortusewicz, Malini Rajan, Ulrich Rothbauer, Alexander Rapp
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 779-788 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 779-788 (2015)
Highlights • An alpaca-derived γ-H2AX nanobody was generated. • γ-H2AX chromobody was able to bind and precipitate phosphorylated H2AX peptide. • γ-H2AX chromobody could be produced in bacterial as well as mammalian cells. • Alternative ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1823e9dd3b045c07ad18c6c97ff6e71d
https://doi.org/10.1016/j.fob.2015.09.005
https://doi.org/10.1016/j.fob.2015.09.005
Autor:
Murali Ganesan, Shiva Shankar Vangimalla, Larisa Poluektova, Raghubendra Singh Dagur, Weimin Wang, David F. Mercer, Irina Tikhanovich, Kusum K. Kharbanda, Natalia A. Osna, Yimin Sun, Steven A. Weinman, Dean J. Tuma
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 101-112 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 101-112 (2018)
Background & Aims Alcohol-induced progression of hepatitis C virus (HCV) infection is related to dysfunction of innate immunity in hepatocytes. Endogenously produced interferon (IFN)α induces activation of interferon-stimulated genes (ISGs) via trig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c76494f71746f876cb19cccb914ea12
https://pubmed.ncbi.nlm.nih.gov/29693039
https://pubmed.ncbi.nlm.nih.gov/29693039