Zobrazeno 1 - 10
of 43 440
pro vyhledávání: '"siRNA"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Chronic inflammation and NLRP3 inflammasome activation are among the determining factors of breast malignancies. Paclitaxel (PTX) is a drug used in breast cancer treatment which sustains prolonged inflammation, reducing the effectiveness of
Externí odkaz:
https://doaj.org/article/7cea1cd7940a44d3ad68974f26a90af6
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Integrin α5β1 plays a crucial role in the invasion of nonphagocytic cells by Staphylococcus aureus (S. aureus), thereby facilitating infection development. Lipid nanoparticles (LNPs) serve as an effective vehicle for delivering
Externí odkaz:
https://doaj.org/article/fcf470d92454439c8069091008fa2160
Autor:
Ming Li, Yuanyuan Li, Jun Zheng, Zhen Ma, Jianye Zhang, Hao Wu, Yangyang Zhu, Pan Li, Fang Nie
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract The immunosuppressive tumor microenvironment (TME) significantly inhibits the effective anti-tumor immune response, greatly affecting the efficacy of immunotherapy. Most tumor-associated macrophages (TAMs) belong to the M2 phenotype, which c
Externí odkaz:
https://doaj.org/article/94b4a401689348a28447768f5a8172f3
Autor:
Nan Lu, Qiming Jiang, Tianshu Xu, Qiyuan Gao, Yuepeng Wang, Zixian Huang, Zhiquan Huang, Xiaoding Xu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background Long noncoding RNAs (lncRNAs) are widely involved in cancer development and progression, but the functions of most lncRNAs have not yet been elucidated. Metastasis is the main factor restricting the therapeutic outcomes of various
Externí odkaz:
https://doaj.org/article/0a11748ea24b45ee8ffd428befa11991
Autor:
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 1107-1114 (2024)
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region. Despite the fact that
Externí odkaz:
https://doaj.org/article/5cf5cec5475f4820943040c215bfd52c
Autor:
Shima Hasani, Mohammad Khalaj-Kondori, Sahar Safaei, Mohammad Amini, Negin Riazi-Tabrizi, Mohadeseh Maghsoudi, Behzad Baradaran
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Gastric cancer (GC) is a highly chemoresistant malignancy with a poor prognosis. Paclitaxel’s low response rate as second-line chemotherapy for advanced GC has prompted intensive research into its molecular basis and prospective
Externí odkaz:
https://doaj.org/article/ba01d739403343a9ba23d91f293e5ba4
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3802-3817 (2024)
Small nucleic acid drugs, composed of nucleotides, represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics. These agents function by selectively targeting specific genes or
Externí odkaz:
https://doaj.org/article/5915be80fbe64a2ebe7f9e79127c8733
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Ferroptosis, triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the progression of DOX-induced cardiomyopathy (DIC), and thus limits the use of doxorubicin (DOX) in clinic. Here, we further showed that cardi
Externí odkaz:
https://doaj.org/article/102b7cabe86844e59f2344e309db65bb
Autor:
I. P. Shilovskiy, G. B. Pasikhov, V. V. Smirnov, I. A. Kofiadi, M. V. Popova, P. A. Strueva, M. R. Khaitov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 157-171 (2024)
INTRODUCTION. Small interfering RNAs (siRNAs) are among the most promising types of therapeutic nucleic acids aiming at the inhibition of pathogenetically relevant gene expression through the RNA interference mechanism. However, the limited bioavaila
Externí odkaz:
https://doaj.org/article/eb2d2fbfb84c4e88a2f8d5a7cea9133d
Publikováno v:
Journal of Future Foods, Vol 4, Iss 4, Pp 300-308 (2024)
ABSTRACT: α-Lactalbumin (α-lac), a natural food-sourced protein, exhibits high biocompatibility as delivery systems for small bioactive molecules or RNA. However, their potential clinical application as a delivery system is greatly limited due to t
Externí odkaz:
https://doaj.org/article/4f52986a8e4241588abb58b7a8b7eb95