Zobrazeno 1 - 10
of 2 157
pro vyhledávání: '"shp2"'
Autor:
Michelangelo Marasco, John Kirkpatrick, Teresa Carlomagno, Jochen S. Hub, Massimiliano Anselmi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1169-1180 (2024)
SHP2 is a tyrosine phosphatase that plays a regulatory role in multiple intracellular signaling cascades and is known to be oncogenic in certain contexts. In the absence of effectors, SHP2 adopts an autoinhibited conformation with its N-SH2 domain bl
Externí odkaz:
https://doaj.org/article/0029acf72ec94573abd1f3e2e607cb5f
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Monosodium urate (MSU) crystallisation deposited in local tissues and organs induce inflammatory reactions, resulting in diseases such as gout. MSU has been recognized as a common and prevalent pathology in various clinical conditions. In th
Externí odkaz:
https://doaj.org/article/a5d91389151c4ad2a765c099c7b9f14a
Autor:
Kai Tang, Shu Wang, Siqi Feng, Xinyu Yang, Yueyang Guo, Xiangli Ren, Linyue Bai, Bin Yu, Hong-Min Liu, Yihui Song
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3624-3642 (2024)
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a promising therapeutic target for cancer therapy. In this work, we presented the structure-guided design of 5,6-fused bicyclic allosteric SHP2 inhibitors, leading to the identificati
Externí odkaz:
https://doaj.org/article/c01905b3c96349fa9c33036d200fdba5
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39677- (2024)
Oral squamous cell carcinoma (OSCC) is known to be driven by multiple intricated receptor tyrosine kinases (RTKs) including EGFR, PI3K/AKT and MAPK signaling pathways. However, whilst targeting EGFR with cetuximab has been approved for the treatment
Externí odkaz:
https://doaj.org/article/4d3833f21f594f75aed68e2603d4966a
Autor:
Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Qiang Xu, Jianjun Zou, Yang Sun, Wenjie Guo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2598-2612 (2024)
Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth, differentiation, and survival. The activation of SHP2 has been
Externí odkaz:
https://doaj.org/article/57ae5fb65d544d5eb042d47c5827ece7
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Macrophage-mediated innate immune responses play a crucial role in tumor development. This study revealed the mechanism of SHP-1 in regulating HCC progressi
Externí odkaz:
https://doaj.org/article/0854b304e7c440adbad663ed714bef62
Akademický článek
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Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34008- (2024)
Objective: In gastric cancer cells, the influence of CAR T cells can be produced in the process of inhibiting the progression of gastric cancer, and the role of tyrosine phosphatase SHP2 can be explored in this study, along with its molecular mechani
Externí odkaz:
https://doaj.org/article/72f91482eae142bd8af14a2238c5d4a1
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundYinChen WuLing Powder (YCWLP) has been recommended by consensus for the treatment of non-alcoholic steatohepatitis (NASH); nevertheless, its specific pharmacological mechanisms remain to be elucidated. This study aims to dissect the mechani
Externí odkaz:
https://doaj.org/article/bb8ef66937d9473ab200f4a3a171301e
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33358- (2024)
Objective: This study explores the inhibition of papillary thyroid carcinoma proliferation by Decorin via the EGFR/SHP2/FER pathway. Method: ology: Thirty-two pairs of papillary thyroid carcinoma tissues and adjacent normal tissues were collected for
Externí odkaz:
https://doaj.org/article/f4e959904e9644f6a47f84d9618f96d5