Zobrazeno 1 - 10
of 263
pro vyhledávání: '"shmt2"'
Autor:
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O.
Publikováno v:
Endocrine Regulations, Vol 58, Iss 1, Pp 144-152 (2024)
Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis). The endoplasmic reticulum stress, hypoxia, and glucose and glutamine supply a
Externí odkaz:
https://doaj.org/article/8492f2f39bcd4c8f97216ef7a540237f
Autor:
Zhou, Yufei a, 1, Kang, Le b, 1, Xu, Ran a, 1, Zhao, Di a, 1, Wang, Jienan a, Wu, Jiaying c, Lin, Hong a, Ding, Zhiwen a, ⁎, Zou, Yunzeng a, c, ⁎⁎
Publikováno v:
In Cellular Signalling August 2024 120
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 50, Iss 9, Pp 860-865 (2023)
Objective To explore the molecular mechanism of SHMT2 regulating the invasion and migration of breast cancer cells. Methods Bioinformatics analysis was used to verify the role of SHMT2 in breast cancer tissues. Transwell assay was used to detect the
Externí odkaz:
https://doaj.org/article/03c2eaef3497451da80845115304b098
Autor:
Tianyu Han, Yanan Wang, Minzhang Cheng, Qifan Hu, Xiaorui Wan, Menglin Huang, Yuhan Liu, Wenze Xun, Jin Xu, Lei Wang, Ruiguang Luo, Yi Yuan, Keru Wang, Jianbin Wang
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Targeting cancer‐specific metabolic processes is a promising therapeutic strategy. Here, this work uses a compound library that directly inhibits metabolic enzymes to screen the potential metabolic targets in lung adenocarcinoma (LUAD). SH
Externí odkaz:
https://doaj.org/article/7a116f16e81341c397c524f5a2ac35f1
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Background In recent years, the role of altered cellular metabolism in tumor progression has attracted widespread attention. Related metabolic enzymes have also been considered as potential cancer therapeutic targets. Serine hydroxymethyltra
Externí odkaz:
https://doaj.org/article/4850e4f691f649c09886c54e81a7a364
Akademický článek
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Autor:
Li Song, Qiu‐Ling Pan, Gui‐Feng Zhou, Sheng‐Wei Liu, Bing‐Lin Zhu, Pei‐Jia Lin, Xiao‐Tong Hu, Jing‐Si Zha, Yan Long, Biao Luo, Jian Chen, Ying Tang, Jing Tang, Xiao‐Jiao Xiang, Xiao‐Yong Xie, Xiao‐Juan Deng, Guo‐Jun Chen
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract It is long been suggested that one‐carbon metabolism (OCM) is associated with Alzheimer's disease (AD), whereas the potential mechanisms remain poorly understood. Taking advantage of chemical biology, that mitochondrial serine hydroxymethy
Externí odkaz:
https://doaj.org/article/05748bcfdf2b4138810dae2b4810b884
Publikováno v:
PeerJ, Vol 12, p e16594 (2024)
Background Gastric cancer (GC) is one of the most common malignant tumours in the digestive system. Serine hydroxymethyltransferase 2 (SHMT2) is one of the key enzymes associated with serine metabolism. However, the prognostic role of SHMT2 in GC car
Externí odkaz:
https://doaj.org/article/709895209c7d4fd9ad67ab072e1c9936
Publikováno v:
Cell Journal, Vol 25, Iss 4, Pp 222-228 (2023)
Objective: Gastric cancer is the fifth most common neoplasm and the fourth reason for mortality globally. Incidencerates are highly variable and dependent on risk factors, epidemiologic and carcinogenesis patterns. Previous studiesreported that Helic
Externí odkaz:
https://doaj.org/article/9c39fb5057e44e1c8ee92a9055ed10f5
Akademický článek
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