Zobrazeno 1 - 10
of 22
pro vyhledávání: '"sherin zakaria"'
JNK inhibitor and ferroptosis modulator as possible therapeutic modalities in Alzheimer disease (AD)
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer disease (AD) is among the most prevalent neurodegenerative diseases globally, marked by cognitive and behavioral disruptions. Ferroptosis is a form of controlled cell death characterized by intracellular iron accumulation associate
Externí odkaz:
https://doaj.org/article/ed132d9a3bcb4a698ce2fd93b665c359
Publikováno v:
Neuroglia, Vol 4, Iss 3, Pp 191-208 (2023)
Alzheimer’s disease (AD) is one of the major causes of dementia and its incidence represents approximately 60–70% of all dementia cases worldwide. Many theories have been proposed to describe the pathological events in AD, including deterioration
Externí odkaz:
https://doaj.org/article/ee639215614f485c94078b1d58e047d2
Publikováno v:
Saudi Pharmaceutical Journal, Vol 30, Iss 8, Pp 1170-1180 (2022)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death. The major challenge in managing HCC is the resistance to chemotherapy. Leptin hormone is associated with different oncogenic pathways implicated in drug resistance.
Externí odkaz:
https://doaj.org/article/c2ba476938344ac3b1978a342abecd69
Tissue Inhibitor of Metalloproteinase 3 as a potential staging biomarker in hepatocellular carcinoma
Publikováno v:
Journal of the Pakistan Medical Association, Vol 73, Iss 4 (2023)
Objective: To assess the potential role of tissue inhibitor of metalloproteinase 3 as a staging marker of hepatocellular carcinoma. Method: The experimental study was conducted at Faculty of Pharmacy, Kafrelsheikh University, Egypt, from December 202
Externí odkaz:
https://doaj.org/article/9fbd6f76943f49c2af9fa9291def0b24
Autor:
Mamdouh M. El-Shishtawy, Nabil M. Abdel-Hamid, Sherin Zakaria, Reem A. Nawaya, Ramadan A. Eldomany
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 18:187-199
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers, asso-ciated with a high rate of mortality. A disturbance between cell proliferation and cell death is one of the cancer hallmarks including HCC. Cell proliferation is mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955b442b15a311fba452e29f2bcf47e4
https://doi.org/10.2174/1574892817666220321161318
https://doi.org/10.2174/1574892817666220321161318
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 18
Background: Solid tumors such as colon cancer are characterized by rapid and sustained cell proliferation, which ultimately results in hypoxia, induction of hypoxia-inducible factor-1α (HIF-1α), and activation of glycolysis to promote tumor surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b2852bc9d8423258d27f7e8b16de73
https://doi.org/10.2174/1574892818666230116142606
https://doi.org/10.2174/1574892818666230116142606
Publikováno v:
Current Molecular Pharmacology. 14:900-913
Background: Hepatocellular carcinoma (HCC) is the 6th prevalent cancer and the 4th leading cause of cancer-related deaths all over the world. A major challenge for sorafenib, the standard chemotherapeutic agent in HCC treatment, is the chemo-resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d8593685f260a276b6af76a799df73a
https://doi.org/10.2174/1874467214666210126110627
https://doi.org/10.2174/1874467214666210126110627
Publikováno v:
Bulletin of Pharmaceutical Sciences. Assiut.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a615763922d154c8309aeccf68944eb8
https://doi.org/10.21608/bfsa.2022.163940.1514
https://doi.org/10.21608/bfsa.2022.163940.1514
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 154
Hypoxic microenvironment of colon cancer is associated with HIF-1α upregulation. HIF-1α response elements are responsible for autophagy induction that promotes tumor proliferation. Moreover, HIF-1α induces tumor cell proliferation via maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8965a9e2ced42caef8899dffc7e2d1a9
https://pubmed.ncbi.nlm.nih.gov/35994813
https://pubmed.ncbi.nlm.nih.gov/35994813
Autor:
Alaa E. El-Sisi, Sherin Zakaria
Publikováno v:
Current Molecular Pharmacology. 13:318-327
Background: Hepatic fibrosis is the major issue in chronic liver diseases such as chronic hepatitis C virus (HCV). The newly approved direct acting antiviral (DAA) agents such as Sofosbuvir (SOF) and daclatasvir (DAC) have been found to be associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac03b91811c32a5a872441f0d714cb42
https://doi.org/10.2174/1874467213666200116114919
https://doi.org/10.2174/1874467213666200116114919