Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs

Autor: Gaojie Song, Jie Yang, Shengzhao Xu, Na Li, Minghui Niu, Deqiang Yao, Jie Yan, Guisheng Zhong

Publikováno v: The Journal of Biological Chemistry

The adhesion G protein–coupled receptor CD97 and its ligand complement decay-accelerating factor CD55 are important binding partners in the human immune system. Dysfunction in this binding has been linked to immune disorders such as multiple sclero

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https://doi.org/10.1016/j.jbc.2021.100776

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Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs.

Autor: Niu M; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Xu S; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Yang J; iHuman Institute, ShanghaiTech University, Shanghai, China., Yao D; iHuman Institute, ShanghaiTech University, Shanghai, China., Li N; National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, CAS, Shanghai, China., Yan J; Department of Physics, National University of Singapore, Singapore., Zhong G; iHuman Institute, ShanghaiTech University, Shanghai, China., Song G; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: gjsong@bio.ecnu.edu.cn.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100776. Date of Electronic Publication: 2021 May 14.