Zobrazeno 1 - 10
of 11 091
pro vyhledávání: '"sh-sy5y"'
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 73-82 (2024)
Neuroblastomas are pediatric tumors arising from undifferentiated cells of neural crest origin with stem cell-like characteristics. Dysregulation of Wnt/β-catenin signaling has been shown to be linked to the development of various tumors. Activated
Externí odkaz:
https://doaj.org/article/306a87f63d1a4d5cb607bb23c9bc73ea
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Neurodegenerative diseases (NDDs) present significant challenges due to limited treatment options, ethical concerns surrounding traditional animal models, and the time-consuming and costly process of using human-induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/8d6fcf1c87ad4891982aede737fb459d
Autor:
Mohamed Abdelmonem, Norazalina Saad, Huey Fang Teh, Ahmad Kamil Mohd Jaaffar, Mohamed Ahmed Ibrahim, Maha A. Alhadad, Che Azurahanim Che Abdullah
Publikováno v:
Nano Biomedicine and Engineering, Vol 16, Iss 3, Pp 386-401 (2024)
Neurodegenerative diseases (NDDs) encompass numerous disorders affecting the nervous system’s structure and functions, primarily caused by protein aggregation, oxidative stress, and inflammation. These factors make a significant contribution to the
Externí odkaz:
https://doaj.org/article/95c24c2509134108b0bcdddea4ec57bf
Autor:
Nurul Fatihah Mohamad Nasir, Muhammad Syahir Hakimi Mohd Hazli, Shaharum Shamsuddin, Azalina Zainuddin
Publikováno v:
Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-9 (2024)
Abstract Background The process of differentiating neuroblastoma cells (SH-SY5Y) is crucial for obtaining mature neuronal markers. However, there is variability in the concentrations of foetal bovine serum (FBS) used in the differentiation media, ran
Externí odkaz:
https://doaj.org/article/41e2aa6b2c0545d191e58ae633ed6194
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 289, Iss , Pp 117464- (2025)
The mechanisms by which T-2 toxin induces senescence in neurons, along with the involvement of hypoxia-inducible factor-1α (HIF-1α), remain poorly understood. Using human neuroblastoma SH-SY5Y cells as a model, T-2 toxin (6 nM, 1–48 h) induced se
Externí odkaz:
https://doaj.org/article/3e0eae3892704a52ba327de039f81484
Publikováno v:
Toxicology Reports, Vol 13, Iss , Pp 101762- (2024)
Therapeutic approaches based on isolated compounds derived from natural products are more common in preventing diseases involving inflammation and oxidative stress at present. S-allyl cysteine (SAC) is a promising garlic-derived organosulfur compound
Externí odkaz:
https://doaj.org/article/eac404ca0bc546c2ab5aec0effd9eb23
Autor:
Jenelle Rolli, Keenan Pearson, Brandon Wilbanks, Sybil C.L. Hrstka, Andrew P. Minotti, Lorenz Studer, Arthur E. Warrington, Nathan P. Staff, L. James Maher, III
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102392- (2024)
There is an urgent need for agents that promote health and regeneration of cells and tissues, specifically to treat diseases of the aging nervous system. Age-associated nervous system degeneration and various diseases are driven by many different bio
Externí odkaz:
https://doaj.org/article/50636c7a7e084603b44902c8caf9abb9
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Chronic alcohol consumption may alter mRNA methylation and expression levels of genes related to addiction and reward in the brain, potentially contributing to alcohol tolerance and dependence. Neuron-like (SH-SY5Y) and non-neuronal (SW620) cells wer
Externí odkaz:
https://doaj.org/article/11bdb85898814fce9515f930437d368e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Parkinson’s disease is a pathology with a wide range of in vivo and in vitro models available. Among these, the SH-SY5Y neuroblastoma cell line is one of the most employed. This model expresses catecholaminergic markers and can differentiate and ac
Externí odkaz:
https://doaj.org/article/8cecbf95dc1147e6972fa91f33006625
Publikováno v:
Phytomedicine Plus, Vol 4, Iss 4, Pp 100643- (2024)
Background: The fusarium verticillioides produces the mycotoxin fumonisin b1 (Fb1), commonly infects corn and other agricultural commodities. The Fb1 showed hepatotoxicity, cytotoxicity, and carcinogenicity in animals. Aim of the study: There are lim
Externí odkaz:
https://doaj.org/article/163f94b9ad6b4d5fa0f4b2ca99594559