Zobrazeno 1 - 10
of 122
pro vyhledávání: '"serine palmitoyl transferase"'
Autor:
Shahanas Chathoth, Mona H. Ismail, Hanan M. Alghamdi, Hazem Mohamed Zakaria, Khairi Ahmed Hassan, Saeed Alshomimi, Chittibabu Vatte, Cyril Cyrus, Hind S. Alsaif, Ahmed Mostafa, Heba Shaaban, Amein Al Ali
Publikováno v:
Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-9 (2022)
Abstract Background Obesity and diabetes are two chronic metabolic diseases whose prevalence is increasing at an alarming rate globally. A close association between obesity, diabetes, and insulin resistance has been identified, and many studies have
Externí odkaz:
https://doaj.org/article/ff07e54bacd349ca8ebdfe642588bcb1
Akademický článek
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Publikováno v:
Cell & Bioscience, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic compartments, whether th
Externí odkaz:
https://doaj.org/article/8fbc619418284c128b9654bd3ba8b5c3
Akademický článek
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Autor:
Jean-Philip Truman, Christian F. Ruiz, Emily Montal, Monica Garcia-Barros, Izolda Mileva, Ashley J. Snider, Yusuf A. Hannun, Lina M. Obeid, Cungui Mao
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100154- (2022)
Cancer cells may depend on exogenous serine, depletion of which results in slower growth and activation of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosine kinase 1 (SK1) in ca
Externí odkaz:
https://doaj.org/article/e13c757acba64c0c8e8bee3ea201beb3
Autor:
Osamu Sano, Ken‐ichi Kazetani, Ryutaro Adachi, Osamu Kurasawa, Tomohiro Kawamoto, Hidehisa Iwata
Publikováno v:
FEBS Open Bio, Vol 7, Iss 4, Pp 495-503 (2017)
Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate‐limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis‐
Externí odkaz:
https://doaj.org/article/81c20fbc2dc8451390aee1661eb2137b
Akademický článek
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Autor:
Nur Şebnem Ersöz, Aysun Adan
Publikováno v:
Proceedings, Vol 40, Iss 1, p 4 (2019)
Sphingolipids are important signaling lipids which play crucial roles to determine the cell fate. Ceramide, apoptotic central molecule of sphingolipid metabolism, which is produced through de novo pathway by serine palmitoyl transferase (SPT) and can
Externí odkaz:
https://doaj.org/article/ae265e3c33634eb0af04f9b38f85647b
Autor:
Osman Oğuz, Aysun Adan
Publikováno v:
Proceedings, Vol 40, Iss 1, p 3 (2019)
The mechanisms underlying the growth inhibitory effect of resveratrol on Ph+ ALL cells were investigated with regard to targeting of ceramide metabolism and changes in BCR-ABL expression. Growth inhibition and apoptotic effects of resveratrol, SK inh
Externí odkaz:
https://doaj.org/article/c28c75f64298462e927f07a942a2e181
Autor:
Wanida Ruangsiriluk, Shaun E. Grosskurth, Daniel Ziemek, Max Kuhn, Shelley G. des Etages, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1459-1471 (2012)
Dysregulation of ceramide synthesis has been associated with metabolic disorders such as atherosclerosis and diabetes. We examined the changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by
Externí odkaz:
https://doaj.org/article/43d09733156841e98dea15d49809a06f