Human Rotaviruses of Multiple Genotypes Acquire Conserved VP4 Mutations during Serial Passage.

Autor: Carter MH; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Gribble J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Diller JR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Denison MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Mirza SA; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Chappell JD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Halasa NB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Ogden KM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Publikováno v: Viruses [Viruses] 2024 Jun 18; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 18.

Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets.

Autor: Zhang Y; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China., Si L; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China., Gao J; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China., Shu X; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China., Qiu C; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China., Zhang Y; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China., Zu S; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China., Hu H; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China.; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan, China.

Publikováno v: MSystems [mSystems] 2024 Mar 19; Vol. 9 (3), pp. e0134623. Date of Electronic Publication: 2024 Feb 13.

Assessing the impact of meropenem exposure on ceftolozane/tazobactam-resistance development in Pseudomonas aeruginosa using in vitro serial passage.

Autor: Fouad A; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, USA., Nicolau SE; mRNA Center of Excellence, Sanofi Pasteur, Waltham, MA, USA., Tamma PD; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Simner PJ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, USA.; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA., Gill CM; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, USA.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2024 May 02; Vol. 79 (5), pp. 1176-1181.

Human Rotaviruses of Multiple Genotypes Acquire Conserved VP4 Mutations during Serial Passage

Autor: Maximilian H. Carter, Jennifer Gribble, Julia R. Diller, Mark R. Denison, Sara A. Mirza, James D. Chappell, Natasha B. Halasa, Kristen M. Ogden

Publikováno v: Viruses, Vol 16, Iss 6, p 978 (2024)

Human rotaviruses exhibit limited tropism and replicate poorly in most cell lines. Attachment protein VP4 is a key rotavirus tropism determinant. Previous studies in which human rotaviruses were adapted to cultured cells identified mutations in VP4.

Externí odkaz: https://doaj.org/article/be898c080a3541a38760c10025dd7ee2

Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.

Autor: Curlin JZ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.; ADEAR Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Schmitt K; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., Tibbitts CV; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., O'Connor S; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Marx P; Department of Tropical Medicine, School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.; Tulane National Primate Research Center, Covington, Louisiana, USA., Akkina R; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.

Publikováno v: Journal of medical primatology [J Med Primatol] 2023 Oct; Vol. 52 (5), pp. 290-293. Date of Electronic Publication: 2023 Sep 01.