Zobrazeno 1 - 10
of 798
pro vyhledávání: '"sequence conservation"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background The vast majority of findings from human genome-wide association studies (GWAS) map to non-coding sequences, complicating their mechanistic interpretations and clinical translations. Non-coding sequences that are evolutionarily co
Externí odkaz:
https://doaj.org/article/f46c7b75482842408ef3f280b5419a43
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 889-898 (2023)
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides. Among the three receptor families, i.e., P1, P2X, and P2Y, the P1 and P2Y receptors share common
Externí odkaz:
https://doaj.org/article/749558e0d01f4d63b305ba38c8c141b3
Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/e9872139fb274af298e2e2a67d2a337e
Publikováno v:
Current Research in Structural Biology, Vol 5, Iss , Pp 100099- (2023)
Long Intergenic Non-coding RNAs (lincRNAs) are the largest class of long non-coding RNAs in eukaryotes, originating from the genome's intergenic regions. A ∼4 kb long lincRNA-p21 is derived from a transcription unit next to the p21/Cdkn1a gene l
Externí odkaz:
https://doaj.org/article/f0889f51bb4148ca8f887df0879fb88d
Akademický článek
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Autor:
Juan Luis Pacheco-Garcia, Matteo Cagiada, Kelly Tienne-Matos, Eduardo Salido, Kresten Lindorff-Larsen, Angel L. Pey
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Recent advances in DNA sequencing technologies are revealing a large individual variability of the human genome. Our capacity to establish genotype-phenotype correlations in such large-scale is, however, limited. This task is particularly challenging
Externí odkaz:
https://doaj.org/article/ac7e3935ec344ca1bc48f1470a5bf2f1
Autor:
Sonia Verma, Soumyananda Chakraborti, Om P. Singh, Veena Pande, Rajnikant Dixit, Amit V. Pandey, Kailash C. Pandey
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundThe thyroid hormone receptor-like (THR-like) family is the largest transcription factors family belonging to the nuclear receptor superfamily, which directly binds to DNA and regulates the gene expression and thereby controls various metabo
Externí odkaz:
https://doaj.org/article/24149ac5374b4fb0a5a09993499b636e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Protein-DNA interactions play a crucial role in gene expression and regulation. Identifying the DNA binding surface of proteins has long been a challenge–in comparison to protein-protein interactions, limited progress has been made in the developme
Externí odkaz:
https://doaj.org/article/0756ed9181834f42babda582356140c7
Autor:
João Trigueiro-Louro, Vanessa Correia, Inês Figueiredo-Nunes, Marta Gíria, Helena Rebelo-de-Andrade
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2117-2131 (2020)
There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a struc
Externí odkaz:
https://doaj.org/article/a92e138139094ccea9f09fa631c8d277
Autor:
Li Chuin Chong, Asif M. Khan
Publikováno v:
BMC Genomics, Vol 20, Iss S9, Pp 1-18 (2019)
Abstract Background The sequence diversity of dengue virus (DENV) is one of the challenges in developing an effective vaccine against the virus. Highly conserved, serotype-specific (HCSS), immune-relevant DENV sequences are attractive candidates for
Externí odkaz:
https://doaj.org/article/28cf739ba2804a49a3d3721e2b1496bc