Stem cells repurpose proliferation to contain a breach in their niche barrier

Autor: Kenneth Lay, Shaopeng Yuan, Shiri Gur-Cohen, Yuxuan Miao, Tianxiao Han, Shruti Naik, H Amalia Pasolli, Samantha B Larsen, Elaine Fuchs

Publikováno v: eLife, Vol 7 (2018)

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt

Externí odkaz: https://doaj.org/article/e217a64595114d78aad05d549c5117f9

Stem cells repurpose proliferation to contain a breach in their niche barrier.

Autor: Lay K; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Yuan S; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Gur-Cohen S; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Miao Y; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Han T; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Naik S; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Pasolli HA; Electron Microscopy Shared Resource, Howard Hughes Medical Institute, Janelia Research Campus, Virginia, United States., Larsen SB; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States., Fuchs E; Robin Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

Publikováno v: ELife [Elife] 2018 Dec 06; Vol. 7. Date of Electronic Publication: 2018 Dec 06.