Zobrazeno 1 - 10
of 230
pro vyhledávání: '"senotherapy"'
Autor:
Christopher Bolton
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-24 (2024)
Abstract Historical survey confirms that, over the latter part of the 20th century, autoimmune-based diseases, including multiple sclerosis (MS), have shown a worldwide increase in incidence and prevalence. Analytical population studies have establis
Externí odkaz:
https://doaj.org/article/97195ed032f74bd6bf3cf147e3590079
Autor:
Andrew Oliveira Silva, Thais Cardoso Bitencourt, Jose Eduardo Vargas, Lucas Rosa Fraga, Eduardo Filippi-Chiela
Publikováno v:
Genetics and Molecular Biology, Vol 47, Iss suppl 1 (2024)
Abstract Senescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senes
Externí odkaz:
https://doaj.org/article/7985ae2e4eee4ebc914be328d0a3b137
Autor:
Aikaterini E. Mantadaki, Stella Baliou, Manolis Linardakis, Elena Vakonaki, Manolis N. Tzatzarakis, Aristides Tsatsakis, Emmanouil K. Symvoulakis
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1136 (2024)
Telomeres, the protective chromosomal ends, progressively shorten and potentially are implicated in the pathogenesis of age-related diseases. In type 2 diabetes (T2DM), telomere shortening may play an important role, but the whole ‘picture’ remai
Externí odkaz:
https://doaj.org/article/3396494aed3a4f59b75dfa7c2336a5d8
Publikováno v:
Dermatopathology, Vol 10, Iss 2, Pp 168-172 (2023)
Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were sig
Externí odkaz:
https://doaj.org/article/abc37de0ae574e4f826e762c314e3349
Autor:
Yu Sun
Publikováno v:
Translational Medicine of Aging, Vol 7, Iss , Pp 46-51 (2023)
Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life. Senescent cells are highly associated with organismal aging and
Externí odkaz:
https://doaj.org/article/c65268e77c2e493ea799122dc185bf65
Publikováno v:
Medical Review, Vol 2, Iss 6, Pp 590-610 (2022)
Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both the quantity and quality of oocytes. The molecular mechanisms and various contributing factors underl
Externí odkaz:
https://doaj.org/article/a09b0062b89642c7b33818f0fdef549e
Autor:
Shuai Xiao, Dongmin Qin, Xueyang Hou, Lingli Tian, Yeping Yu, Rui Zhang, Hao Lyu, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stres
Externí odkaz:
https://doaj.org/article/48f71ccf694e4d0b95d740e378a52eb4
Akademický článek
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Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target. Cellular senescence is involved in the pathogenesis of various chronic diseases, including
Externí odkaz:
https://doaj.org/article/da0af1e1faaa494f95463543f9fbb771
Akademický článek
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