Zobrazeno 1 - 10
of 1 309
pro vyhledávání: '"senolytic"'
Autor:
Milena Silva, David A. Wacker, Brian E. Driver, Abbey Staugaitis, Laura J. Niedernhofer, Elizabeth L. Schmidt, James L. Kirkland, Tamara Tchkonia, Tamara Evans, Carlos Hines Serrano, Steffen Ventz, Joseph S. Koopmeiners, Michael A. Puskarich, The STOP-Sepsis Investigators
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Senescent immune cells exhibit altered gene expression and resistance to apoptosis. The prevalence of these cells increases with age and emerging data implicate senescence-associated maladaptive signaling as a potential contributo
Externí odkaz:
https://doaj.org/article/75fb6b81b5be4aa8ac501941ef1ff11d
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology, Vol Volume 17, Pp 2243-2259 (2024)
Huilan Zheng,1 Jingping Wu,2 Jinhong Feng,2 Hongbin Cheng3 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610075, People’s Republic of China; 2Department of Medical Cosmetology, Hospital
Externí odkaz:
https://doaj.org/article/88d65e545151411e81327d4a11c77f43
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Previous studies have reported that senolytic drugs can reverse obesity-mediated accumulation of senescent cells in the ovary and protect against cisplatin-induced ovarian injury by removing senescent cells. Early intervention with ABT-263 h
Externí odkaz:
https://doaj.org/article/dd8dc9bfe46c4d7f88dfaddc5d4e8988
Autor:
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 9, Pp n/a-n/a (2024)
Abstract Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism. The senescence‐associated secretory phenotype (SASP), secreted by senescent t
Externí odkaz:
https://doaj.org/article/be43e037774042de858bd2a5c08c05a6
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundGanoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a variety of diseases. Different extractions from G. lucidum have been used to manage age-related diseases, including cancer. Neverthe
Externí odkaz:
https://doaj.org/article/890410208e9b41e08b6bcdbb7c2a0af5
Autor:
Liang Ma, Jie Yu, Yidian Fu, Xiaoyu He, Shengfang Ge, Renbing Jia, Ai Zhuang, Zhi Yang, Xianqun Fan
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory phenotype. The function of senescent cells in cancer
Externí odkaz:
https://doaj.org/article/5eee344a33a245aa9270e4d2012a1c15
Autor:
Katherine E. Simon, Katharine Russell, Alejandra Mondino, Chin-Chieh Yang, Beth C. Case, Zachary Anderson, Christine Whitley, Emily Griffith, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial.
Externí odkaz:
https://doaj.org/article/fe8940694bdf4905b3f233e0ac4ebea5
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic de
Externí odkaz:
https://doaj.org/article/83e74c013eeb45ac86216a94b447b3eb
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116962- (2024)
Metabolic disorders are considered the hallmarks of cancer and metabolic reprogramming is emerging as a new strategy for cancer treatment. Exogenous and endogenous stressors can induce cellular senescence; the interactions between cellular senescence
Externí odkaz:
https://doaj.org/article/b391e44f5197499ea64859816464ca5d
Autor:
Jasper Iske, Hao Zhou
Publikováno v:
Frontiers in Transplantation, Vol 3 (2024)
Externí odkaz:
https://doaj.org/article/8a89a5fc209a462e9c316e21b63b588f