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Publikováno v:
Current Topics in Medicinal Chemistry. 20:1461-1467
Aims: To explore more active fluoroquinolone anticancer candidates. Background: Cancer which can affect almost any part of the body, is most striking and deadliest disease. It is estimated that around one in five people globally develop cancer during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3c619a9a6987e77e3ff0b603b045d5
https://doi.org/10.2174/1568026620666200128144825
https://doi.org/10.2174/1568026620666200128144825
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:129-133
Analysis of the crystal structure of tyrosine kinase in complexation with an ATP analogue, supplemented with the molecular docking studies of semaxanib and sunitinib in the ATP binding site of the enzyme enabled us to make design of a series of tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957526c9240589ec21001efa7999c836
https://doi.org/10.1016/j.bmcl.2017.11.049
https://doi.org/10.1016/j.bmcl.2017.11.049
Autor:
Shireen Usman, Sreeya Yalamanchali, Dan E. Bruegger, Joel W Jones, Larry A. Hoover, Sufi M. Thomas, Tran B. Le, Ossama Tawfik, Jacob New
Publikováno v:
International Forum of Allergy & Rhinology. 7:973-979
Background Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8e13d1ff3f70f0f5f8487d38361fc04
https://doi.org/10.1002/alr.21987
https://doi.org/10.1002/alr.21987
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1602-1607
In an effort to optimize the structural requirements for combined cytostatic and cytotoxic effects in single agents, a series of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines 3-7 were synthesized and evaluated as inhibitors of receptor tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85a14ff06657af19fa9988cc464652c
https://doi.org/10.1016/j.bmcl.2017.02.018
https://doi.org/10.1016/j.bmcl.2017.02.018
Publikováno v:
Oncotarget
// Edmond F. O’Donnell 1, 2 , Hyo Sang Jang 1, 2 , Martin Pearce 1, 2 , Nancy I. Kerkvliet 2 , Siva Kumar Kolluri 1, 2 1 Cancer Research Laboratory, Oregon State University, Corvallis, Oregon, USA 2 Department of Environmental and Molecular Toxicol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3ae17b2b8ef3d4583fe0da6ddc8773
http://europepmc.org/articles/PMC5421923
http://europepmc.org/articles/PMC5421923
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 120, Iss, Pp-(2019)
Strategies targeting endoglin are currently being investigated in clinical trials as an anti-angiogenic therapy. The redundancy between endoglin and vascular endothelial growth factor (VEGF) signaling in angiogenesis was verified. Increased endoglin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763bc68bfe29d4f5db2a7d9711b22be9
http://www.sciencedirect.com/science/article/pii/S0753332219332214
http://www.sciencedirect.com/science/article/pii/S0753332219332214
Publikováno v:
Toxicology in Vitro. 71:105063
Vascular endothelial growth factor (VEGF) promotes tumor angiogenesis through stimulating the proliferation and survival of endothelial cells. The severe adverse events caused by VEGF inhibitors might include immune-related ones; however, details of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6a75ba817dbd05d5d3c20a142e723d
https://doi.org/10.1016/j.tiv.2020.105063
https://doi.org/10.1016/j.tiv.2020.105063
Publikováno v:
European Journal of Medicinal Chemistry. 200:112359
Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to anticancer agents represents one of the major obstacles for the effective cancer treatment. Indole derivatives have the potential to act on diverse targets in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37d86ca0765a5c935595af2d16948ea
https://doi.org/10.1016/j.ejmech.2020.112359
https://doi.org/10.1016/j.ejmech.2020.112359
Publikováno v:
Archiv der Pharmazie. 353:1900367
The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin-based anticancer agents, such as semaxanib, sunitinib, nintedanib, and hesperadin, are already in use or und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119af5703ba3333e5195ca6c13b5f62d
https://doi.org/10.1002/ardp.201900367
https://doi.org/10.1002/ardp.201900367