Zobrazeno 1 - 10
of 1 357
pro vyhledávání: '"selumetinib"'
Autor:
A. M. Pivovarova, M. Yu. Dorofeeva, A. R. Zabrodina, S. V. Bochenkov, A. V. Grigoryeva, Z. K. Gorchkhanova, V. R. Voronina
Publikováno v:
Русский журнал детской неврологии, Vol 19, Iss 2, Pp 8-19 (2024)
Neurofibromatosis type 1 is a multisystem genetic disorder associated with an increased risk of benign and malignant tumors due to mutations in the NF1 gene. Clinical manifestations of the disease vary and depend on the patient’s age. One of the mo
Externí odkaz:
https://doaj.org/article/b4e6033da53041e09b4872bd981b78d1
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7395-7410 (2024)
Cholangiocellular carcinoma (CCA) is the second most common primary liver cancer, with increasing incidence worldwide and inadequate therapeutic options. Intra- and extrahepatic bile ducts have distinctly different embryonic origins and developmental
Externí odkaz:
https://doaj.org/article/635db1b64ee44c9095f96373b7ccba71
Autor:
Cameron Church, Christian X. Fay, Emil Kriukov, Hui Liu, Ashley Cannon, Lauren Ashley Baldwin, David K. Crossman, Bruce Korf, Margaret R. Wallace, Andrea M. Gross, Brigitte C. Widemann, Robert A. Kesterson, Petr Baranov, Deeann Wallis
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most patients with NF1 develop skin lesions called cutaneous neurofibromas (cNFs). Currently the only approved therapeutic for NF1 is selumetinib, a mitog
Externí odkaz:
https://doaj.org/article/d00a5353dd604d0dbaf40783a4391f24
Autor:
Pilar Anton-Martin, Hitesh Sandhu, Jennifer Kramer, Gary Beasley, Hugo Martinez, Umar S. Boston, Shyam K. Sathanandam, Vijay Agrawal, Abhishek Chakraborty
Publikováno v:
Indian Pediatrics Case Reports, Vol 4, Iss 2, Pp 70-74 (2024)
Background: Pulmonary hemorrhage is a rare cause of morbidity and mortality in children. Extracorporeal membrane oxygenation (ECMO) can be used as a rescue mode of support in children with life-threatening respiratory failure. However, the dilemma ar
Externí odkaz:
https://doaj.org/article/3b4675fdf46d422aa0bb3e215c95e134
Autor:
Margarita Dionysiou, Stavriani C. Makri, Shivani Ahlawat, Melike Guryildirim, Kristin W. Barañano, Mari L. Groves, Pedram Argani, Christine A. Pratilas
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
The RASopathies, collectively, are a spectrum of genetic syndromes caused by mutations in genes involved in the RAS/ mitogen-activated protein kinase (MAPK) pathway, including but not limited to PTPN11, NRAS, KRAS, HRAS, BRAF, and MAP2K1. Recognized
Externí odkaz:
https://doaj.org/article/1276b5df977e4efbbf6f69fcda642fbb
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveTo integrate pharmacovigilance and network toxicology methods to explore the potential adverse drug events (ADEs) and toxic mechanisms of selumetinib, and to provide a reference for quickly understanding the safety and toxicological mechanis
Externí odkaz:
https://doaj.org/article/bdd5c801f03c4287a2d46aaf327efd93
Autor:
Vicenç Ruiz de Porras, Adrià Bernat-Peguera, Clara Alcon, Fernando Laguia, Maria Fernández-Saorin, Natalia Jiménez, Ana Senan-Salinas, Carme Solé-Blanch, Andrea Feu, Mercedes Marín-Aguilera, Juan Carlos Pardo, Maria Ochoa-de-Olza, Joan Montero, Begoña Mellado, Albert Font
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Docetaxel remains the standard treatment for metastatic castration-resistant prostate cancer (mCRPC). However, resistance frequently emerges as a result of hyperactivation of the PI3K/AKT and the MEK/ERK pathways. Therefore, the inhibitio
Externí odkaz:
https://doaj.org/article/15a09439b35e4fa08388d66216c30dd7
Autor:
R. N. Mustafin
Publikováno v:
Сибирский онкологический журнал, Vol 22, Iss 3, Pp 119-124 (2023)
Purpose of the study. Analysis of available data on modern methods of diagnosis and treatment of neurofibromatosis type 1 (NF1) and their application in the Russian Federation. Material and Methods. The search for relevant sources was carried out in
Externí odkaz:
https://doaj.org/article/40668ee5b194456d82620d5f3bc75c83
Autor:
XU Jianing, GUO Yaxin, WANG Shanshan, YIN Lei, ZHU Jiaming, CHENG Wen, JIANG Hongkun, GAO Xinghua, XU Xuegang
Publikováno v:
罕见病研究, Vol 2, Iss 2, Pp 186-190 (2023)
A 3-year-old male patient was diagnosed with neurofibromatosis type 1(NF1) for two years. The patient has multiple neurofibromas in retroperitoneum, lumbococcygeal paravertebral, lumbosacral spinal canal, and foramina. Due to retroperitoneal mass com
Externí odkaz:
https://doaj.org/article/9f378ef8b03b46449ebc61836aec6b4b
Autor:
Andrea Gazzin, Federico Fornari, Simona Cardaropoli, Diana Carli, Marco Tartaglia, Giovanni Battista Ferrero, Alessandro Mussa
Publikováno v:
Life, Vol 14, Iss 6, p 731 (2024)
The RASopathies are a group of syndromes caused by genetic variants that affect the RAS-MAPK signaling pathway, which is essential for cell response to diverse stimuli. These variants functionally converge towards the overactivation of the pathway, l
Externí odkaz:
https://doaj.org/article/9b43c3c9064248b08886248b2271543f