Zobrazeno 1 - 10
of 181
pro vyhledávání: '"self-reactivity"'
Publikováno v:
In Immunity 10 December 2024 57(12):2945-2958
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The selection of high-affinity B cells and the production of high-affinity antibodies are mediated by T follicular helper cells (Tfhs) within germinal centres (GCs). Therein, somatic hypermutation and selection enhance B cell affinity but risk the em
Externí odkaz:
https://doaj.org/article/f2bf46eedb59447aba06618911ecd49a
Autor:
Darina Paprckova, Veronika Niederlova, Alena Moudra, Ales Drobek, Michaela Pribikova, Sarka Janusova, Kilian Schober, Ales Neuwirth, Juraj Michalik, Martina Huranova, Veronika Horkova, Michaela Cesnekova, Michaela Simova, Jan Prochazka, Jana Balounova, Dirk H. Busch, Radislav Sedlacek, Martin Schwarzer, Ondrej Stepanek
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fat
Externí odkaz:
https://doaj.org/article/3d221b08845a4bd9b620763e054dec64
Autor:
Lydia K Lutes, Zoë Steier, Laura L McIntyre, Shraddha Pandey, James Kaminski, Ashley R Hoover, Silvia Ariotti, Aaron Streets, Nir Yosef, Ellen A Robey
Publikováno v:
eLife, Vol 10 (2021)
Functional tuning of T cells based on their degree of self-reactivity is established during positive selection in the thymus, although how positive selection differs for thymocytes with relatively low versus high self-reactivity is unclear. In additi
Externí odkaz:
https://doaj.org/article/7576a36ea73d437fbdb9d9b7a5263164
Akademický článek
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Akademický článek
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Autor:
Åkerstrand, Hugo
Publikováno v:
Lund University, Faculty of Medicine Doctoral Dissertation Series; (2023:89) (2023)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1110::39b6aa8aad313869c8c43888ebb28601
https://lup.lub.lu.se/record/d6c7e942-6c72-49c0-bf26-d4ced5c3297c
https://lup.lub.lu.se/record/d6c7e942-6c72-49c0-bf26-d4ced5c3297c
Autor:
Daniela Langenhorst, Paula Tabares, Tobias Gulde, Bryan R. Becklund, Susanne Berr, Charles D. Surh, Niklas Beyersdorf, Thomas Hünig
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
In rodents, low doses of CD28-specific superagonistic monoclonal antibodies (CD28 superagonists, CD28SA) selectively activate regulatory T cells (Treg). This observation has recently been extended to humans, suggesting an option for the treatment of
Externí odkaz:
https://doaj.org/article/803c85bb94f64da7b18c609ea251a7cd
Autor:
Vincent Guichard, Nelly Bonilla, Aurélie Durand, Alexandra Audemard-Verger, Thomas Guilbert, Bruno Martin, Bruno Lucas, Cédric Auffray
Publikováno v:
eLife, Vol 6 (2017)
Continuous contact with self-major histocompatibility complex ligands is essential for the survival of naive CD4 T cells. We have previously shown that the resulting tonic TCR signaling also influences their fate upon activation by increasing their a
Externí odkaz:
https://doaj.org/article/94567a29547547ca9924e9be8b13ab44
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/6fe0c47aeafd4abb8c7022005306cfdc