Zobrazeno 1 - 10
of 206
pro vyhledávání: '"self-amplifying RNA"'
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract The efficacy and safety of self‐amplifying mRNA (saRNA) have been demonstrated in COVID‐19 vaccine applications. Unlike conventional non‐replicating mRNA (nrmRNA), saRNA offers a key advantage: its self‐replication mechanism fosters
Externí odkaz:
https://doaj.org/article/1cb904fa97be42d9a2cd0aaf3eefdd34
Autor:
Paul K. Kitandwe, Paul Rogers, Kai Hu, Owen Nayebare, Anna K. Blakney, Paul F. McKay, Pontiano Kaleebu, Robin J. Shattock
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1088 (2024)
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that causes high fetal and neonatal mortality rates in ruminants and sometimes severe to fatal complications like encephalitis and hemorrhagic fever in humans. There is no licensed RVF vaccin
Externí odkaz:
https://doaj.org/article/7cf85b1d32ae42a9b8fc69a8c7bda419
Autor:
Shuo WANG, Jianmin LI
Publikováno v:
Zhongguo gonggong weisheng, Vol 39, Iss 4, Pp 514-520 (2023)
Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can b
Externí odkaz:
https://doaj.org/article/877d7d0a990e442198308c2e3b7d23a5
Autor:
Jonathan Kitonsa, Onesmus Kamacooko, Eugene Ruzagira, Florence Nambaziira, Andrew Abaasa, Jennifer Serwanga, Ben Gombe, Jane Lunkuse, Hadijah Naluyinda, Naboth Tukamwesiga, Tamara Namata, Antony Kigozi, Paddy Kafeero, Vincent Basajja, Sarah Joseph, Benjamin F. Pierce, Robin Shattock, Pontiano Kaleebu
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
We report the screening and enrollment process for a phase I vaccine trial in Masaka, Uganda that investigated the safety and immunogenicity of a self-amplifying SARS-CoV-2 RNA vaccine amongst individuals with and without antibodies to SARS-CoV-2. Pa
Externí odkaz:
https://doaj.org/article/43ef80eb00424f8a9af701b04bf37501
Publikováno v:
Viruses, Vol 16, Iss 4, p 503 (2024)
Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines. Unlike in vitro transcribed mRNA found in most current RNA vaccines, saRNA or taRN
Externí odkaz:
https://doaj.org/article/33f7b923942443fe854b4bcfe3326bf0
Publikováno v:
Vaccines, Vol 12, Iss 3, p 318 (2024)
SARS-CoV-2 virus, the causative agent of COVID-19, has produced the largest pandemic in the 21st century, becoming a very serious health problem worldwide. To prevent COVID-19 disease and infection, a large number of vaccines have been developed and
Externí odkaz:
https://doaj.org/article/139d0f19d6304fa4a690277c39523b73
Autor:
Noelia Silva-Pilipich, Aritz Lasarte-Cía, Teresa Lozano, Celia Martín-Otal, Juan José Lasarte, Cristian Smerdou
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 387-399 (2022)
Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy. These vectors are usually delivered as viral
Externí odkaz:
https://doaj.org/article/b1f921f31651413ab141c0f1f87c97c4
Autor:
Eduarda Santos Lima, Déborah dos Santos, Atena Liriel Souza, Maria Eduarda Macedo, Mariana Evangelista Bandeira, Sérgio Santos Silva Junior, Bianca Sampaio Dotto Fiuza, Vinicius Pinto Costa Rocha, Larissa Moraes dos Santos Fonseca, Danielle Devequi Gomes Nunes, Katharine Valéria Saraiva Hodel, Bruna Aparecida Souza Machado
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1634 (2023)
Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges to more traditional methods. RNA-based therapies have emerged as a promising avenue, utilizing nanoformulation treatments to target a range
Externí odkaz:
https://doaj.org/article/2145d4dc0cc94c0391eb2ea193342013
Autor:
Takenao Koseki, Mayumi Teramachi, Minako Koga, Minoru S. H. Ko, Tomokazu Amano, Hong Yu, Misa Amano, Erica Leyder, Maria Badiola, Priyanka Ray, Jiyoung Kim, Akihiro C. Ko, Achouak Achour, Nan-ping Weng, Takumi Imai, Hisako Yoshida, Satsuki Taniuchi, Ayumi Shintani, Hidetsugu Fujigaki, Masashi Kondo, Yohei Doi
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1767 (2023)
mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have played a key role in reducing morbidity and mortality from coronavirus disease 2019 (COVID-19). We conducted a double-blind, placebo-controlled phase I/II trial t
Externí odkaz:
https://doaj.org/article/18beafabbfdd4081a2b1ad576923e462
Autor:
Shi Du, Wenqing Li, Yuebao Zhang, Yonger Xue, Xucheng Hou, Jingyue Yan, Jeffrey Cheng, Binbin Deng, David W. McComb, Jennifer Lin, Hong Zeng, Xiaolin Cheng, Darrell J. Irvine, Ron Weiss, Yizhou Dong
Publikováno v:
Advanced Science, Vol 10, Iss 11, Pp n/a-n/a (2023)
Abstract Male infertility caused by genetic mutations is an important type of infertility. Currently, there is no reliable method in the clinic to address this medical need. The emergence of mRNA therapy provides a possible strategy for restoring mut
Externí odkaz:
https://doaj.org/article/9d73ad80650f478b8530e1d5629c2893