Evaluation of the Anti-Inflammatory and Chondroprotective Effect of Celecoxib on Cartilage Ex Vivo and in a Rat Osteoarthritis Model

Autor: Mirella J.J. Haartmans, Ufuk Tan Timur, Kaj S. Emanuel, Marjolein M.J. Caron, Ralph M. Jeuken, Tim J.M. Welting, Gerjo J.V.M. van Osch, Ron M.A. Heeren, Berta Cillero-Pastor, Pieter J. Emans

Publikováno v: Cartilage, 13(3):19476035221115541. SAGE Publications Inc.
Cartilage, 13(3). SAGE Publishing
Cartilage, 13(3). SAGE Publications Inc.

Objective The potential chondroprotective effect of celecoxib, a nonsteroidal anti-inflammatory drug and selective cyclooxygenase-2 inhibitor used to reduce pain and inflammation in knee osteoarthritis patients, is disputed. This study aimed at inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd8e000f4dc7a5376058e85ace8b628
https://cris.maastrichtuniversity.nl/en/publications/911f73c2-e21d-4d9f-89c4-d1bdf6c00c1f

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

Autor: Smaranda Dafina Oniga, Liliana Pacureanu, Cristina Ioana Stoica, Mariana Doina Palage, Alexandra Crăciun, Laurentiu Răzvan Rusu, Elena-Luminita Crisan, Cătălin Araniciu

Publikováno v: Molecules, Vol 22, Iss 9, p 1507 (2017)

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders. In an effort to obtain safer NSAIDs,

Externí odkaz: https://doaj.org/article/7b03394509ad4c73bf5f0b7e12a26fab

The cannabinoid system and pain

Autor: Victoria Chapman, Andrea G. Hohmann, David P. Finn, Volker Neugebauer, Stephen G. Woodhams

Publikováno v: Neuropharmacology. 124:105-120

Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb861f17d42012d83f7573240e90a44c
https://doi.org/10.1016/j.neuropharm.2017.06.015

Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

Autor: Tellegen, A R, Rudnik-Jansen, I, Pouran, Behdad, Visser, M.H., Weinans, H., Thomas, R E, Kik, M J L, Grinwis, G C M, Thies, J C, Woike, N, Mihov, George, Emans, Pieter J, Meij, B P, Creemers, L.B., Tryfonidou, M A, Orthopedie en neurochirurgie, Veterinair Pathologisch Diagnostisch Cnt, dPB CR, dCSCA RMSC-1, dCSCA AVR, LS Algemene chirurgie, LS Pathobiologie, dPB RMSC, dPB I&I, Sub Physical Oceanography

Publikováno v: Drug delivery, 25(1), 1438. Informa Healthcare
Drug Delivery
Current Drug Delivery, 25(1), 1438. Bentham Science Publishers B.V.
Drug Delivery, 25(1), 1438-1447. Routledge/Taylor & Francis Group
Drug Delivery, Vol 25, Iss 1, Pp 1438-1447 (2018)

Major hallmarks of osteoarthritis (OA) are cartilage degeneration, inflammation and osteophyte formation. COX-2 inhibitors counteract inflammation-related pain, but their prolonged oral use entails the risk for side effects. Local and prolonged admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833fc52951a1611cad29aeee95b5013a
https://dspace.library.uu.nl/handle/1874/365153

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