Zobrazeno 1 - 10
of 196
pro vyhledávání: '"seed sequence"'
Autor:
Joshua M. Corbin, Constantin Georgescu, Lin Wang, Jonathan D. Wren, Magdalena Bieniasz, Chao Xu, Adam S. Asch, Maria J. Ruiz Echevarría
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 257-272 (2023)
Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate cancer (PCa). However, acquired resistance to single agents targeting this pathway results in the development of lethal castration-resistant PCa. Combination therap
Externí odkaz:
https://doaj.org/article/41fabf28d4364d8697b56a2f8a9cd7e7
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Viral proteins encode numerous antiviral activities to modify the host immunity. In this article, we hypothesize that viral genomes and gene transcripts interfere with host gene expression using passive mechanisms to deregulate host microRNA (miRNA)
Externí odkaz:
https://doaj.org/article/355ba273d2c04332abd90b29ad2cd2a8
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
MicroRNAs (miRNAs), important factors in animal innate immunity, suppress the expressions of their target genes by binding to target mRNA’s 3′ untranslated regions (3′UTRs). However, the mechanism of synchronous regulation of multiple targets b
Externí odkaz:
https://doaj.org/article/972ee9d65d874dbfb49630461f1a2ed7
Autor:
Andrius Serva, Pranas Grigaitis, Ursula Kummer, Vytaute Starkuviene, Ursula Rost, Pascal Pucholt
Publikováno v:
RNA Biol
Grigaitis, P, Starkuviene, V, Rost, U, Serva, A, Pucholt, P & Kummer, U 2020, ' miRNA target identification and prediction as a function of time in gene expression data ', RNA Biology, vol. 17, no. 7, pp. 990-1000 . https://doi.org/10.1080/15476286.2020.1748921
RNA Biology, 17(7), 990-1000. Landes Bioscience
Grigaitis, P, Starkuviene, V, Rost, U, Serva, A, Pucholt, P & Kummer, U 2020, ' miRNA target identification and prediction as a function of time in gene expression data ', RNA Biology, vol. 17, no. 7, pp. 990-1000 . https://doi.org/10.1080/15476286.2020.1748921
RNA Biology, 17(7), 990-1000. Landes Bioscience
The understanding of miRNA target interactions is still limited due to conflicting data and the fact that high-quality validation of targets is a time-consuming process. Faster methods like high-throughput screens and bioinformatics predictions are e
Autor:
Bridget F. Donnelly, Bing Yang, Acadia L. Grimme, Karl-Frédéric Vieux, Chen-Yu Liu, Lecong Zhou, Katherine McJunkin
MicroRNA (miRNA) abundance is tightly controlled by regulation of biogenesis and decay. Here we show that the mir-35 miRNA family undergoes selective decay at the transition from embryonic to larval development in C. elegans. The seed sequence of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f70ea246f36c042804648a82e9884c
https://doi.org/10.1101/2021.11.19.469346
https://doi.org/10.1101/2021.11.19.469346
MicroRNA are short and non-coding RNA, 18-25 nucleotides in length. They are produced at the early stage of viral infection. The roles played by cellular miRNAs and miRNA-mediated gene-silencing in the COVID-19 epidemic period is critical in order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d7691d09236256e9de1580de004873
Publikováno v:
Bioinformatics
MicroRNAs (miRNAs) function as master regulators of gene expression in many physiological and pathological conditions including cancer. Sequence variants or isoforms (isomiRs) can account for between 40 to 60% of total miRNA counts, yet despite this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdc3d89c57cb0d10b8de2306b6670ed
https://doi.org/10.1101/2020.08.20.259713
https://doi.org/10.1101/2020.08.20.259713
Publikováno v:
Cold Spring Harb Symp Quant Biol
microRNAs (miRNAs) are crucial for post-transcriptional regulation of messenger RNAs. “Classical” miRNA targets predominantly interact with the miRNA seed sequence located in the miRNA 5′ region. Interestingly, certain transcripts that exhibit