Zobrazeno 1 - 10
of 1 132
pro vyhledávání: '"secretory granule"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Intracellular protein trafficking and sorting are extremely arduous in endocrine and neuroendocrine cells, which synthesize and secrete on-demand substantial quantities of proteins. To ensure that neuroendocrine secretion operates correctly, each ste
Externí odkaz:
https://doaj.org/article/5049cf6173e747568ee9942736bf0fe0
Autor:
Gaya P. Yadav, Haiyuan Wang, Joke Ouwendijk, Stephen Cross, Qiaochu Wang, Feng Qin, Paul Verkade, Michael X. Zhu, Qiu-Xing Jiang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Regulated secretion is conserved in all eukaryotes. In vertebrates granin family proteins function in all key steps of regulated secretion. Phase separation and amyloid-based storage of proteins and small molecules in secretory granules require ion h
Externí odkaz:
https://doaj.org/article/6131dfdd178c45dfabdca389df5982b8
Autor:
Toledo, Pamela L., Vazquez, Diego S., Gianotti, Alejo R., Abate, Milagros B., Wegbrod, Carolin, Torkko, Juha M., Solimena, Michele, Ermácora, Mario R.
ICA512/PTPRN is a receptor tyrosine-like phosphatase implicated in the biogenesis and turnover of the insulin secretory granules (SGs) in pancreatic islet beta cells. Previously we found biophysical evidence that its luminal RESP18 homology domain (R
Externí odkaz:
https://tud.qucosa.de/id/qucosa%3A86847
https://tud.qucosa.de/api/qucosa%3A86847/attachment/ATT-0/
https://tud.qucosa.de/api/qucosa%3A86847/attachment/ATT-0/
Publikováno v:
Diagnostics, Vol 13, Iss 17, p 2859 (2023)
Type 1 diabetes (T1D) is a chronic autoimmune disease that attacks the insulin-producing b cells of the pancreatic islets. Autoantibodies to b cell proteins typically appear in the circulation years before disease onset, and serve as the most accurat
Externí odkaz:
https://doaj.org/article/f37c4cfbf24749cab36b288ffc18da7a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13109 (2023)
The hypothalamus regulates fundamental aspects of physiological homeostasis and behavior, including stress response, reproduction, growth, sleep, and feeding, several of which are affected in patients with Prader–Willi (PWS) and Schaaf–Yang syndr
Externí odkaz:
https://doaj.org/article/3ea172af7b2146c6b0bd7c38d5753ae9
Akademický článek
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Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9560 (2023)
Transport models are extremely important to map thousands of proteins and their interactions inside a cell. The transport pathways of luminal and at least initially soluble secretory proteins synthesized in the endoplasmic reticulum can be divided in
Externí odkaz:
https://doaj.org/article/a69f245c30d44a51a5b275e80972eebb
Autor:
Cheng-I Jonathan Ma, Julie A. Brill
Publikováno v:
Communicative & Integrative Biology, Vol 14, Iss 1, Pp 15-20 (2021)
Secretory granules (SGs) are organelles responsible for regulated exocytosis of biologically active molecules in professional secretory cells. Maturation of SGs is a crucial process in which cargoes of SGs are processed and activated, allowing them t
Externí odkaz:
https://doaj.org/article/a2f57b1d80d6421894d31f4b373bbf1a
Autor:
Debdeep Chatterjee, Reeba S Jacob, Soumik Ray, Ambuja Navalkar, Namrata Singh, Shinjinee Sengupta, Laxmikant Gadhe, Pradeep Kadu, Debalina Datta, Ajoy Paul, Sakunthala Arunima, Surabhi Mehra, Chinmai Pindi, Santosh Kumar, Praful Singru, Sanjib Senapati, Samir K Maji
Publikováno v:
eLife, Vol 11 (2022)
Synergistic-aggregation and cross-seeding by two different proteins/peptides in the amyloid aggregation are well evident in various neurological disorders including Alzheimer’s disease. Here, we show co-storage of human Prolactin (PRL), which is as
Externí odkaz:
https://doaj.org/article/54d99c7977ee49a782c1221d6dd5f8b3