Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

Autor: Shushan Ge, Haiqing Zhong, Xuewei Ma, Yingbo Zheng, Yi Zou, Fang Wang, Yan Wang, Yue Hu, Yuezhen Li, Wen Liu, Wenjie Guo, Qiang Xu, Yisheng Lai

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1240-1257 (2020)

Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the

Externí odkaz: https://doaj.org/article/999492738840416e803d20a2a0c7249a

Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies

Autor: Claudiu T. Supuran, Anna Maria Marini, Monica Viviano, Federico Da Settimo, Sandro Cosconati, Elisabetta Barresi, Sabrina Taliani, Silvia Salerno, Sabrina Castellano, Emanuela Berrino, Emma Baglini, Rahul Ravichandran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1874-1883 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342dce90661ec300940c15a810da5bde
https://doaj.org/article/88031813ab9443118c310ad8a0e3ccdb

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

Autor: Paolo Guglielmi, Melissa D'Ascenzio, Daniela Secci, Mariangela Ceruso, Atilla Akdemir, Adriano Mollica, Claudiu T. Supuran, Simone Carradori, Anatoly P. Sobolev, Rosalba Florio

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 51-59 (2017)
Journal of enzyme inhibition and medicinal chemistry
32 (2017): 51–59. doi:10.1080/14756366.2016.1235040
info:cnr-pdr/source/autori:D'Ascenzio, Melissa; Guglielmi, Paolo; Carradori, Simone; Secci, Daniela; Florio, Rosalba; Mollica, Adriano; Ceruso, Mariangela; Akdemir, Atilla; Sobolev, Anatoly P.; Supuran, Claudiu T./titolo:Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms/doi:10.1080%2F14756366.2016.1235040/rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2017/pagina_da:51/pagina_a:59/intervallo_pagine:51–59/volume:32
Journal of Enzyme Inhibition and Medicinal Chemistry

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd827baf89624b6b44aad246c4dd9233
https://doi.org/10.1080/14756366.2016.1235040

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