The influence of three-dimensional structure on naïve T cell homeostasis and aging

Autor: Simon Lambert, Wenqiang Cao, Huimin Zhang, Alex Colville, Jie-Yu Liu, Cornelia M. Weyand, Jorg J. Goronzy, Claire E. Gustafson

Publikováno v: Frontiers in Aging, Vol 3 (2022)

A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains r

Externí odkaz: https://doaj.org/article/f3199be1e3fa4f94bf796c88b8c360ea

Altered T-cell subset distribution in the viral reservoir in HIV-1-infected individuals with extremely low proviral DNA

Autor: Galvez, C, Urrea, V, Garcia-Guerrero, MD, Bernal, S, Benet, S, Mothe, B, Bailon, L, Dalmau, J, Martinez, A, Nieto, A, Leal, L, Garcia, F, Clotet, B, Martinez-Picado, J, Salgado, M

Publikováno v: Journal of Internal Medicine
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Background HIV cure strategies aim to eliminate viral reservoirs that persist despite successful antiretroviral therapy (ART). We have previously described that 9% of HIV-infected individuals who receive ART harbor low levels of provirus (LoViReTs).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::8f3f377e357714bc3dee1be1f21e5d40
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2520

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Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo

Autor: Joseph Guarnaccia, Margarita Dominguez-Villar, Ann Caroline Danielsen, David A. Hafler, Khadir Raddassi

Publikováno v: J Autoimmun

Fingolimod is an approved therapeutic option for patients with relapsing-remitting multiple sclerosis that primarily functions by sequestering T cells in lymph nodes inhibiting their egress to the central nervous system. However, recent data suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c629f6b2e8ea069b4fc74043ef8296
https://pubmed.ncbi.nlm.nih.gov/31109655

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