Zobrazeno 1 - 10
of 425
pro vyhledávání: '"secondary degeneration"'
Autor:
Ben C. Orem, Johnny R. Morehouse, Spencer Ames, Darlene A. Burke, David S.K. Magnuson, David P. Stirling
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 433-446 (2022)
Neuronal ryanodine receptors (RyR) release calcium from internal stores and play a key role in synaptic plasticity, learning, and memory. Dysregulation of RyR function contributes to neurodegeneration and negatively impacts neurological recovery afte
Externí odkaz:
https://doaj.org/article/d2ba62b72e794ac49db69c31c3781f07
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102945- (2022)
Secondary white matter degeneration is a common occurrence after ischemic stroke, as identified by Diffusion Tensor Imaging (DTI). However, despite recent advances, the time course of the process is not completely understood. The primary aim of this
Externí odkaz:
https://doaj.org/article/467d967339534a768fab5223958f08ff
Autor:
Marco Aurelio M. Freire, Rafael Rodrigues Lima, Leonardo Oliveira Bittencourt, Joanilson S. Guimaraes, Daniel Falcao, Walace Gomes-Leal
Publikováno v:
Cells, Vol 12, Iss 3, p 457 (2023)
Secondary degeneration is defined as a set of destructive events that damage cells and structures that were initially spared or only peripherally affected by the primary insult, constituting a key factor for functional impairment after traumatic brai
Externí odkaz:
https://doaj.org/article/0c7bf1a71d914907a3b4a3e285919bd2
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 4, Pp 728-734 (2019)
Running is believed to be beneficial for human health. Many studies have focused on the neuroprotective effects of voluntary running on animal models. There were both primary and secondary degeneration in neurodegenerative diseases, including glaucom
Externí odkaz:
https://doaj.org/article/8494ea61a98f42f5b2f3de1f3d72ee5f
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Ischemic lesions could lead to secondary degeneration in remote regions of the brain. However, the spatial distribution of secondary degeneration along with its role in functional deficits is not well understood. In this study, we explored the spatia
Externí odkaz:
https://doaj.org/article/a37ff920253f4271b255a69799cbec06
Akademický článek
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Autor:
Ryan L. O’Hare Doig, Sreya Santhakumar, Brooke Fehily, Sushmitha Raja, Tanya Solomon, Carole A. Bartlett, Melinda Fitzgerald, Stuart I. Hodgetts
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to in
Externí odkaz:
https://doaj.org/article/14d6a50030fe4f2fbbe32f497cbe1789
Autor:
Nicole M. Smith, Marcus K. Giacci, Alexander Gough, Charlotte Bailey, Terence McGonigle, Anna M. B. Black, Thomas O. Clarke, Carole A. Bartlett, K. Swaminathan Iyer, Sarah A. Dunlop, Melinda Fitzgerald
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Following injury to the central nervous system, increased microglia, secretion of pro- and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark of degeneration, are observed at and immediately adja
Externí odkaz:
https://doaj.org/article/0b49ca1779304d90a76e7d98fb19b1fa
Autor:
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metab
Externí odkaz:
https://doaj.org/article/1f6e5113e52a4da8841df25ed981e229
Autor:
Nathanael J Yates, Marcus K Giacci, Ryan L O'Hare Doig, Wissam Chiha, Bethany E Ashworth, Jade Kenna, Carole A Bartlett, Melinda Fitzgerald
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 2, Pp 307-316 (2017)
Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the com
Externí odkaz:
https://doaj.org/article/342b253e6c554f1892dae1202575c069