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Akademický článek

Blood myeloid cells differentiate to lung resident cells and respond to pathogen stimuli in a 3D human tissue-engineered lung model

Autor: Mandi M. Roe, Taylor Do, Sean Turner, Allison M. Jevitt, Magdalena Chlebicz, Karley White, Antonius G. P. Oomens, Susannah Rankin, Susan Kovats, Heather Gappa-Fahlenkamp

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Introduction: Respiratory infections remain a leading global health concern. Models that recapitulate the cellular complexity of the lower airway of humans will provide important information about how the immune response reflects the interactions bet

Externí odkaz: https://doaj.org/article/acae8c0bf39240649276fd674b4043e5

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Akademický článek

Gram-Positive Bacteria Cell Wall Peptidoglycan Polymers Activate Human Dendritic Cells to Produce IL-23 and IL-1β and Promote TH17 Cell Differentiation

Autor: Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajaña, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats

Publikováno v: Microorganisms, Vol 11, Iss 1, p 173 (2023)

Gram-positive bacterial infections are a major cause of organ failure and mortality in sepsis. Cell wall peptidoglycan (PGN) is shed during bacterial replication, and Bacillus anthracis PGN promotes a sepsis-like pathology in baboons. Herein, we dete

Externí odkaz: https://doaj.org/article/76338808118045a094a816262c2f125b

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Akademický článek

'gcamdata': An R Package for Preparation, Synthesis, and Tracking of Input Data for the GCAM Integrated Human-Earth Systems Model

Publikováno v: Journal of Open Research Software, Vol 7, Iss 1 (2019)

The increasing data requirements of complex models demand robust, reproducible, and transparent systems to track and prepare models’ inputs. Here we describe version 1.0 of the gcamdata R package that processes raw inputs to produce the hundreds of

Externí odkaz: https://doaj.org/article/9dbcf15cf0384ccc9de5dfe5e2b22202

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Akademický článek

The method of producing climate change datasets impacts the resulting policy guidance and chance of mal-adaptation

Autor: Marie Ekström, Michael Grose, Craig Heady, Sean Turner, Jin Teng

Publikováno v: Climate Services, Vol 4, Iss C, Pp 13-29 (2016)

Impact, adaptation and vulnerability (IAV) research underpin strategies for adaptation to climate change and help to conceptualise what life may look like in decades to come. Research draws on information from global climate models (GCMs) though typi

Externí odkaz: https://doaj.org/article/0ed455c2b5cc4f1da55972f032b60c66

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Akademický článek

The Paris pledges and the energy-water-land nexus in Latin America: Exploring implications of greenhouse gas emission reductions.

Autor: Silvia R Santos Da Silva, Fernando Miralles-Wilhelm, Raul Muñoz-Castillo, Leon E Clarke, Caleb J Braun, Alison Delgado, James A Edmonds, Mohamad Hejazi, Jill Horing, Russell Horowitz, Page Kyle, Robert Link, Pralit Patel, Sean Turner, Haewon C McJeon

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0215013 (2019)

In the 2015 Paris Agreement, nations worldwide pledged emissions reductions (Nationally Determined Contributions-NDCs) to avert the threat of climate change, and agreed to periodically review these pledges to strengthen their level of ambition. Previ

Externí odkaz: https://doaj.org/article/c4e96bd86d9a46f99d33f05ec8b168be

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Akademický článek

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

Autor: He Li, Tove Ragna Reksten, John A Ice, Jennifer A Kelly, Indra Adrianto, Astrid Rasmussen, Shaofeng Wang, Bo He, Kiely M Grundahl, Stuart B Glenn, Corinne Miceli-Richard, Simon Bowman, Sue Lester, Per Eriksson, Maija-Leena Eloranta, Johan G Brun, Lasse G Gøransson, Erna Harboe, Joel M Guthridge, Kenneth M Kaufman, Marika Kvarnström, Deborah S Cunninghame Graham, Ketan Patel, Adam J Adler, A Darise Farris, Michael T Brennan, James Chodosh, Rajaram Gopalakrishnan, Michael H Weisman, Swamy Venuturupalli, Daniel J Wallace, Kimberly S Hefner, Glen D Houston, Andrew J W Huang, Pamela J Hughes, David M Lewis, Lida Radfar, Evan S Vista, Contessa E Edgar, Michael D Rohrer, Donald U Stone, Timothy J Vyse, John B Harley, Patrick M Gaffney, Judith A James, Sean Turner, Ilias Alevizos, Juan-Manuel Anaya, Nelson L Rhodus, Barbara M Segal, Courtney G Montgomery, R Hal Scofield, Susan Kovats, Xavier Mariette, Lars Rönnblom, Torsten Witte, Maureen Rischmueller, Marie Wahren-Herlenius, Roald Omdal, Roland Jonsson, Wan-Fai Ng, for UK Primary Sjögren's Syndrome Registry, Gunnel Nordmark, Christopher J Lessard, Kathy L Sivils

Publikováno v: PLoS Genetics, Vol 13, Iss 6, p e1006820 (2017)

Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debili

Externí odkaz: https://doaj.org/article/de75960e36dc428c8be5c64c20d692ba

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Akademický článek

Regional responses to future, demand-driven water scarcity

Autor: Ryna Yiyun Cui, Katherine Calvin, Leon Clarke, Mohamad Hejazi, Son Kim, Page Kyle, Pralit Patel, Sean Turner, Marshall Wise

Publikováno v: Environmental Research Letters, Vol 13, Iss 9, p 094006 (2018)

This paper explores regional response strategies to potential water scarcity. Using a model of integrated human-earth system dynamics (GCAM), we test a wide range of alternate water demand scenarios to explore regional response strategies. We create

Externí odkaz: https://doaj.org/article/597257f2325b499dacd05dc74b409923

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