Zobrazeno 1 - 10
of 696
pro vyhledávání: '"scrnaseq"'
Autor:
Yang Li, Yuhong Ding, Yaxin Hou, Lilong Liu, Zhenghao Liu, Zhipeng Yao, Pengjie Shi, Jinxu Li, Ke Chen, Junyi Hu
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Background Aging of the male prostate is an inevitable process in which the prostate undergoes hyperplasia, and this growth may lead to compression of the urethra, resulting in voiding dysfunction and associated symptoms, and an increased ri
Externí odkaz:
https://doaj.org/article/8e287193782444828662a42ec345c17e
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background Single-cell RNA sequencing (scRNAseq) offers powerful insights, but the surge in sample sizes demands more computational power than local workstations can provide. Consequently, high-performance computing (HPC) systems have become
Externí odkaz:
https://doaj.org/article/e7a275eb60d043e194a07f71d45b8ba6
Autor:
George I. Gavriilidis, Vasileios Vasileiou, Aspasia Orfanou, Naveed Ishaque, Fotis Psomopoulos
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1886-1896 (2024)
Recent advances in single-cell omics technology have transformed the landscape of cellular and molecular research, enriching the scope and intricacy of cellular characterisation. Perturbation modelling seeks to comprehensively grasp the effects of ex
Externí odkaz:
https://doaj.org/article/d3c22f06af104b499987087d08ffdb03
Autor:
Alison G. Cole, Julia Steger, Julia Hagauer, Andreas Denner, Patricio Ferrer Murguia, Paul Knabl, Sanjay Narayanaswamy, Brittney Wick, Juan D. Montenegro, Ulrich Technau
Publikováno v:
Frontiers in Zoology, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background The recent combination of genomics and single cell transcriptomics has allowed to assess a variety of non-conventional model organisms in much more depth. Single cell transcriptomes can uncover hidden cellular complexity and cell
Externí odkaz:
https://doaj.org/article/8d252e401de54519b580529173ec1b18
Autor:
Jonas Mattisson, Jonatan Halvardson, Hanna Davies, Bożena Bruhn-Olszewska, Paweł Olszewski, Marcus Danielsson, Josefin Bjurling, Amanda Lindberg, Ammar Zaghlool, Edyta Rychlicka-Buniowska, Jan P. Dumanski, Lars A. Forsberg
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer. It h
Externí odkaz:
https://doaj.org/article/3fb79618f8b24d1694b937e0dfc03697
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33367- (2024)
Ovarian cancer represents a severe gynecological malignancy with a dire prognosis, underscoring the imperative need for dependable biomarkers that can accurately predict drug response and guide therapeutic choices. In this study, we harnessed online
Externí odkaz:
https://doaj.org/article/fcc23d9ab5154269a290c10bda9f0c73
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Sindbis virus (SINV) infection of mice provides a model system for studying the pathogenesis of alphaviruses that infect the central nervous system (CNS) to cause encephalomyelitis. While studies of human viral infections typically focus on
Externí odkaz:
https://doaj.org/article/ad916e75113642aeadd7afeebedd49bd
Autor:
Alberto Ayllon-Hermida, Marc Nicolau-Fernandez, Ane M. Larrinaga, Iris Aparici-Herraiz, Elisabet Tintó-Font, Oriol Llorà-Batlle, Agnes Orban, María Fernanda Yasnot, Mariona Graupera, Manel Esteller, Jean Popovici, Alfred Cortés, Hernando A. del Portillo, Carmen Fernandez-Becerra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Recent studies indicate that human spleen contains over 95% of the total parasite biomass during chronic asymptomatic infections caused by Plasmodium vivax. Previous studies have demonstrated that extracellular vesicles (EVs) secreted from infected r
Externí odkaz:
https://doaj.org/article/4c0c66b50a03457bb1b958779ad6f4d4
Autor:
Puja Mehta, Blanca Sanz-Magallón Duque de Estrada, Emma K. Denneny, Kane Foster, Carolin T. Turner, Andreas Mayer, Martina Milighetti, Manuela Platé, Kaylee B. Worlock, Masahiro Yoshida, Jeremy S. Brown, Marko Z. Nikolić, Benjamin M. Chain, Mahdad Noursadeghi, Rachel C. Chambers, Joanna C. Porter, Gillian S. Tomlinson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPersistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities are interpreted to indicate subacute inflammation whereas reticulation is though
Externí odkaz:
https://doaj.org/article/0c20d7c4f93849d0869626a0bd37c791
Publikováno v:
F1000Research, Vol 11 (2024)
Cell-to-cell gene expression variability is an inherent feature of complex biological systems, such as immunity and development. Single-cell RNA sequencing is a powerful tool to quantify this heterogeneity, but it is prone to strong technical noise.
Externí odkaz:
https://doaj.org/article/8d5516786c9e414fa9d451d50d717f59