Zobrazeno 1 - 10
of 1 741
pro vyhledávání: '"screening assay"'
Autor:
Yirui Zhai, Fan Wu, Xin Xu, Pan Zhao, Lingxia Xin, Mengyuan Li, Yuan Zong, Zhuanbo Yang, Zhuoran Li, Liming Wang, Bo Chen
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34484- (2024)
Hepatocellular carcinoma (HCC) is the major cause of cancer-associated mortality worldwide. Despite great advances have been made on the treatment of HCC, the survival rate of patients remains poor. Spindle apparatus coiled-coil protein 1 (SPDL1) is
Externí odkaz:
https://doaj.org/article/69092c308ca44f228b7328297c4c4e5f
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 309-318 (2023)
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD). To inhibit ODC, α-difluoromethylornithine (DFMO), an irreversible ODC inhibitor, has
Externí odkaz:
https://doaj.org/article/8e991f6027494d0c8cedf211026e0c59
Autor:
Arkadi Kundik, Zaneta D. Musimbi, Jürgen Krücken, Thomas Hildebrandt, Oleg Kornilov, Susanne Hartmann, Friederike Ebner
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background Helminth infections are an important public health problem in humans and have an even greater impact on domestic animal and livestock welfare. Current readouts for anthelmintic drug screening assays are stage development, migratio
Externí odkaz:
https://doaj.org/article/3bf7861bab0a45ef95d6cd20080837f2
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 180-187 (2023)
JAK2 transmits signals of several important cytokines, such as growth hormone and erythropoietin. The interest toward the therapeutic targeting of JAK2 was boosted in 2005, when the somatic JAK2 V617F mutation, responsible for the majority of myelopr
Externí odkaz:
https://doaj.org/article/1e1bca33a08c483781dffbd076c780d1
Autor:
Danqi Zeng, Can Si, Jaime A. Teixeira da Silva, Hongyu Shi, Jing Chen, Lei Huang, Juan Duan, Chunmei He
Publikováno v:
BMC Plant Biology, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Gibberellins (GAs) are widely involved in plant growth and development. DELLA proteins are key regulators of plant development and a negative regulatory factor of GA. Dendrobium officinale is a valuable traditional Chinese medicin
Externí odkaz:
https://doaj.org/article/2a0ee2be366441408423d54cae94fc22
Akademický článek
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Akademický článek
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Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 114-120 (2022)
Malaria, an infectious disease caused by protozoan parasites from the genus Plasmodium, represents a serious global health threat. The continued emergence of drug resistant strains has severely decreased current antimalarial drug efficacy and led to
Externí odkaz:
https://doaj.org/article/31a4dc3758e94b47bcd8468f4acc1b13
Autor:
Bryce J. Stanhope, Brittany Peterson, Brittany Knight, Ray Nobles Decadiz, Roger Pan, Phillip Davis, Anne Fraser, Manunya Nuth, Jesse vanWestrienen, Erik Wendlandt, Bruce Goodwin, Christopher Myers, Jennifer Stone, Shanmuga Sozhamannan
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Many SARS-CoV-2 variants have emerged during the course of the COVID-19 pandemic. These variants have acquired mutations conferring phenotypes such as increased transmissibility or virulence, or causing diagnostic, therapeutic, or immune escape. Dete
Externí odkaz:
https://doaj.org/article/a258b75c53654f76891c90b541149048
Autor:
John Ridley, Sam Manyweathers, Raymond Tang, Tom Goetze, Nadine Becker, Ilka Rinke-Weiß, Robert Kirby, Alison Obergrussberger, Marc Rogers
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Human acid-sensing ion channels (ASIC) are ligand-gated ionotropic receptors expressed widely in peripheral tissues as well as sensory and central neurons and implicated in detection of inflammation, tissue injury, and hypoxia-induced acidosis. This
Externí odkaz:
https://doaj.org/article/61c831d9f2354b6c893911150dfa5e52