Zobrazeno 1 - 10
of 979
pro vyhledávání: '"scd1"'
Publikováno v:
Heliyon, Vol 10, Iss 23, Pp e40388- (2024)
Circadian disruption is a risk factor for Parkinson's disease (PD). Ferroptosis, a cellular death process, assumes a pivotal role in the degeneration of dopaminergic neurons in PD. Despite its significance, the potential contribution of circadian clo
Externí odkaz:
https://doaj.org/article/228e266030734704a3b0923de8e3e9e9
Autor:
Toshikatsu Ikeda, Yuki Katoh, Hirotsugu Hino, Daichi Seta, Tadashi Ogawa, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Shuichi Hirai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Stearoyl-CoA desaturase 1 (SCD1) is an attractive target for cancer therapy. However, the clinical efficacy of SCD1 inhibitor monotherapy is limited. There is thus a need to elucidate the mechanisms of resistance to SCD1 inhibition and devel
Externí odkaz:
https://doaj.org/article/f3aa575b4baa416fbc0f3b6f8f9c264e
Autor:
Nerea Moreno, Maria Sabater-Arcis, Teresa Sevilla, Manuel Perez Alonso, Jessica Ohana, Ariadna Bargiela, Ruben Artero
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-17 (2024)
Abstract Background We recently reported that upregulation of Musashi 2 (MSI2) protein in the rare neuromuscular disease myotonic dystrophy type 1 contributes to the hyperactivation of the muscle catabolic processes autophagy and UPS through a reduct
Externí odkaz:
https://doaj.org/article/90b2edade99644b7abd7de2526c613a2
Autor:
Juwon Lee, Suin Jang, Jihye Im, Youngjin Han, Soochi Kim, HyunA Jo, Wenyu Wang, Untack Cho, Se Ik Kim, Aeran Seol, Boyun Kim, Yong Sang Song
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract Ovarian cancer is a leading cause of death among gynecologic tumors, often detected at advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors driving cancer cell growth. Stearoyl-CoA desaturase 1 (SCD1) is
Externí odkaz:
https://doaj.org/article/3b0c54992f8c43b0b925bf7c596656d2
Autor:
Fenghao Geng, Li Zhong, Tingyi Yang, Jianhui Chen, Ping Yang, Fengdi Jiang, Tao Yan, Bin Song, Zuxiang Yu, Daojiang Yu, Jie Zhang, Jianping Cao, Shuyu Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract The extensive application of nuclear technology has increased the potential of uncontrolled radiation exposure to the public. Since skin is the largest organ, radiation‐induced skin injury remains a serious medical concern. Organisms evolu
Externí odkaz:
https://doaj.org/article/767829106ab54aa4ad63b0c8c3873e4b
Autor:
Jiaping Chen, Rong Zhao, Yangwei Wang, Han Xiao, Wei Lin, Mingxin Diao, Shiwen He, Peiyuan Mei, Yongde Liao
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen dependence, suggest that
Externí odkaz:
https://doaj.org/article/6f48c0fa2f0043918a3e2d9b2cefc0bf
Autor:
Piotr Kostusiak, Emilia Bagnicka, Beata Żelazowska, Magdalena Zalewska, Tomasz Sakowski, Jan Slósarz, Marcin Gołębiewski, Kamila Puppel
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1309 (2024)
The objective of this study is to assess the influence of genetic polymorphisms in DGAT1, LEP, and SCD1 on the oxidative stress biomarkers and bioactive protein levels in Hereford bulls. A total of sixty-eight bulls were analyzed at 22 months of age
Externí odkaz:
https://doaj.org/article/a1f6422c03b24615bca456fd6df90e2c
Autor:
Hiroyuki Mori, Sydney K. Peterson, Rachel C. Simmermon, Katherine A. Overmyer, Akira Nishii, Emma Paulsson, Ziru Li, Annie Jen, Romina M. Uranga, Jessica N. Maung, Warren T. Yacawych, Kenneth T. Lewis, Rebecca L. Schill, Taryn Hetrick, Ryo Seino, Ken Inoki, Joshua J. Coon, Ormond A. MacDougald
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101916- (2024)
Objective: Exposure of adipocytes to ‘cool’ temperatures often found in the periphery of the body induces expression of Stearoyl-CoA Desaturase-1 (Scd1), an enzyme that converts saturated fatty acids to monounsaturated fatty acids. The goal of th
Externí odkaz:
https://doaj.org/article/f76e22ea51ec4cc08977dd19997e3c5d
Autor:
Lucia Cilenti, Jacopo Di Gregorio, Rohit Mahar, Fei Liu, Camilla T. Ambivero, Muthu Periasamy, Matthew E. Merritt, Antonis S. Zervos
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Obesity is a growing epidemic affecting millions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality. Accumulating evidence suggests that mitochondria have a profound role in diet-induced obesity an
Externí odkaz:
https://doaj.org/article/4e9129dc645344a9b0a8a2258082e805
Autor:
Qifeng Xiao, Zhongmin Lan, Shuisheng Zhang, Hu Ren, Shunda Wang, Peng Wang, Lin Feng, Dan Li, Chengfeng Wang, Xiaofeng Bai, Jianwei Zhang
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-14 (2023)
Abstract Background Pancreatic cancer is a malignancy with high mortality. Once diagnosed, effective treatment strategies are limited and the five-year survival is extremely poor. Recent studies have shown that zinc finger proteins play important rol
Externí odkaz:
https://doaj.org/article/dbc95ff000b74989956f7d123a0d8e39