FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Autor: Adam J. Mead, Shabnam Kharazi, Deborah Atkinson, Iain Macaulay, Christian Pecquet, Stephen Loughran, Michael Lutteropp, Petter Woll, Onima Chowdhury, Sidinh Luc, Natalija Buza-Vidas, Helen Ferry, Sally-Ann Clark, Nicolas Goardon, Paresh Vyas, Stefan N. Constantinescu, Ewa Sitnicka, Claus Nerlov, Sten Eirik W. Jacobsen

Publikováno v: Cell Reports, Vol 3, Iss 6, Pp 1766-1776 (2013)

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradox

Externí odkaz: https://doaj.org/article/703445d2063749ebb29c59b6e36d5091

Single-Cell Transcriptome Analysis Reveals Pathways That Drive Dyserythropoiesis in Myelodysplastic Syndromes, Which Are Targeted By Luspatercept

Autor: Onima Chowdhury, Douglas RA Silveira, Sophie Reed, Jennifer O'Sullivan, Sally-Ann Clark, Neil Ashley, Bethan Psaila, Supat Thongjuea, Adam J Mead, Lynn Quek

Publikováno v: Blood. 140:9753-9754

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef5c0a0f2fed58f99bfd6c311937ed5e
https://doi.org/10.1182/blood-2022-165865

Memory cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cells associate with viral control

Autor: Tao Dong, Guihai Liu, Suet Felce, Xuan Yao, Zixi Yin, Anastasia Fries, Alexander Mentzer, Danning Dong, Wenbo Wang, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Peter Wing, Timothy Rostron, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Philip Hublitz, Ryan Beveridge, Jeremy Fry, Jane McKeating, Juthathip Mongkolsapaya, Gavin Screaton, Graham Ogg, Julian Knight, Yanchun Peng

Little is known of the role of cytotoxic CD4+ T-cells in the control of viral replication. Here, we investigate CD4+ T-cell responses to three dominant SARS-CoV-2 epitopes and evaluate antiviral activity, including cytotoxicity and antiviral cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6d7b664e3d46e6705f28f1fe1dab4d
https://doi.org/10.21203/rs.3.rs-1317569/v1

Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing

Autor: Angela Hamblin, Sten Eirik W. Jacobsen, Supat Thongjuea, Adam J. Mead, Benjamin J. Povinelli, Nikolaos Sousos, Alice Giustacchini, Alba Rodriguez-Meira, Bethan Psaila, Verónica Alcolea, Nikolaos Barkas, Sally-Ann Clark, Simon J. McGowan, Gemma Buck, E Louka

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspots in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176373d37a9604c24839e2f2b298512
https://doi.org/10.1016/j.molcel.2019.01.009

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Autor: Peter Hokland, Luca Malcovati, Teresa Mortera-Blanco, Paresh Vyas, Mohsen Karimi, Magnus Tobiasson, Lennart Nilsson, Stefan N. Constantinescu, Rikard Erlandsson, John E. Pimanda, Helen Doolittle, Stephen Taylor, Mtakai Ngara, Laura Stenson, Supat Thongjuea, Pierre Fenaux, Onima Chowdhury, Claus Nerlov, David C. Wedge, Peter J. Campbell, Elli Papaemmanuil, Sten Linnarsson, Christian Scharenberg, Dag Josefsen, Andrea Pellagatti, Eva Hellström-Lindberg, Gudrun Göhring, Eleni Giannoulatou, Sten Eirik W. Jacobsen, Qiaolin Deng, Brigitte Schlegelberger, Kristina Anderson, David G. Bowen, Mario Cazzola, Sally Ann Clark, Iain C. Macaulay, Gunnar Kvalheim, Sara Duarte, Adam J. Mead, Sudhir Tauro, Jacqueline Boultwood, Alice Giustacchini, Ingunn Dybedal, Una Kjällquist, Petter S. Woll, Ashwin Unnikrishnan, Mette Holm, Rickard Sandberg

Publikováno v: Woll, P S, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D C, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A J, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I C, Clark, S A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, M S, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J E, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, S N, Nerlov, C, Nilsson, L, Campbell, P J, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S & Jacobsen, S E W 2014, ' Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo ', Cancer Cell, vol. 25, no. 6, pp. 794-808 . https://doi.org/10.1016/j.ccr.2014.03.036

Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which differentcancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052834e561f5970d9c35830b2bcf9d78
https://doi.org/10.1016/j.ccr.2014.03.036