Zobrazeno 1 - 10
of 2 141
pro vyhledávání: '"safety pharmacology"'
Autor:
Sang-Jin Park, Joung‐Wook Seo, Kang-Hyun Han, Byoung-Seok Lee, Chanyeong Lee, Bong Young Kim, Kyong-Cheol Ko, Yong-Bum Kim
Publikováno v:
Vaccine: X, Vol 20, Iss , Pp 100545- (2024)
The coronavirus disease 2019 (COVID-19) emerged as a major global health crisis, posing significant health, economic, and social challenges. Vaccine development has been a crucial response to the severe-acute-respiratory-syndrome-related coronavirus-
Externí odkaz:
https://doaj.org/article/30a2d4449301445f83a040adb42f0cea
Autor:
A. A. Spasov
Publikováno v:
Безопасность и риск фармакотерапии, Vol 11, Iss 3, Pp 246-251 (2023)
It is strategically critical to secure pharmaceutical independence for Russia by developing the industry using the latest achievements in science and technology. The development of nationally and internationally competitive medicines calls for the ha
Externí odkaz:
https://doaj.org/article/dd3aa4ee8df345779b73859ad50ebaa1
Publikováno v:
eLife, Vol 12 (2023)
Many classes of drugs can induce fatal cardiac arrhythmias by disrupting the electrophysiology of cardiomyocytes. Safety guidelines thus require all new drugs to be assessed for pro-arrhythmic risk prior to conducting human trials. The standard safet
Externí odkaz:
https://doaj.org/article/164b1428954745ecb5d100dfce18f458
Autor:
Hasriadi, Anusara Jongchanapong, Wisuwat Thongphichai, Peththa Wadu Dasuni Wasana, Suchada Sukrong, Rutt Suttisri, Surattana Amnuoypol, Pasarapa Towiwat
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 13, Iss 1, Pp 81-92 (2023)
Background: Clerodendrum petasites, an herbal plant in Thailand, has been used for many years in folk medicine. However, scientific evidence regarding CNS safety pharmacology and antinociceptive activity of C. petasites (CP) has not yet been well cha
Externí odkaz:
https://doaj.org/article/9641e4551b7244cebbcb8079198f45b8
Autor:
Koki Chiba, Ryuichi Kambayashi, Mayu Onozato, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Koichiro Tanaka, Yasunari Kanda, Takeshi Fukushima, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 3, Pp 154-162 (2022)
Imatinib has been reported to induce heart failure and/or QTc prolongation. To better understand their underlying mechanisms, we assessed its effects on cardiohemodynamic, electrocardiographic and echocardiographic variables along with biomarkers of
Externí odkaz:
https://doaj.org/article/fd87e9c0826943c79c0ee21cfceafe87
Autor:
Julia C. Hotek, Julio A. Chirinos, Theodore J. Detwiler, Hillary K. Regan, Christopher P. Regan
Publikováno v:
Physiological Reports, Vol 11, Iss 11, Pp n/a-n/a (2023)
Abstract Pulsatile hemodynamics analyses provide important information about the ventricular‐arterial system which cannot be inferred by standard blood pressure measurements. Pulse wave analysis (PWA), wave separation analysis (WSA), and wave power
Externí odkaz:
https://doaj.org/article/dffcf88387414f258b3bf631209c9588
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Akademický článek
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Autor:
Qin Wu, Abigail J. Ross, Tugce Ipek, Georgina H. Thompson, Robert D. Johnson, Changhao Wu, Patrizia Camelliti
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The cardiotoxicity risk of hydroxychloroquine (HCQ) and azithromycin (AZM) has been the subject of intensive research triggered by safety concerns in COVID-19 patients. HCQ and AZM have been associated with QT interval prolongation and drug-induced a
Externí odkaz:
https://doaj.org/article/b6da9934a8844a17b964cae91e0b70e9