Zobrazeno 1 - 10
of 85
pro vyhledávání: '"sacha howell"'
Autor:
Sally Anne Pearson, Sally Taylor, Antonia Marsden, Jessica Dalton O’Reilly, Ashma Krishan, Sacha Howell, Janelle Yorke
Publikováno v:
Systematic Reviews, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background The review aimed to investigate geographic and sociodemographic factors associated with receipt of systemic anticancer therapies (SACT) for women with secondary (metastatic) breast cancer (SBC). Methods Included studies reported g
Externí odkaz:
https://doaj.org/article/ec85d0c4ad9e43529c8921357cc5ac26
Autor:
Stepan Romanov, Sacha Howell, Elaine Harkness, Megan Bydder, D. Gareth Evans, Steven Squires, Martin Fergie, Sue Astley
Publikováno v:
Tomography, Vol 9, Iss 6, Pp 2103-2115 (2023)
Accurate prediction of individual breast cancer risk paves the way for personalised prevention and early detection. The incorporation of genetic information and breast density has been shown to improve predictions for existing models, but detailed im
Externí odkaz:
https://doaj.org/article/4198fe48becf41f9bd916dfe91a7755f
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced malignancies was designed (ClinicalTrials.gov: NCT03363893). Here we rep
Externí odkaz:
https://doaj.org/article/b14be29b81754bafad04d4aa37714251
Publikováno v:
Breast, Vol 67, Iss , Pp 71-77 (2023)
Polygenic Risk Scores (PRS) are a major component of accurate breast cancer risk prediction and have the potential to improve screening and prevention strategies. PRS combine the risk from Single nucleotide polymorphisms (SNPs) associated with breast
Externí odkaz:
https://doaj.org/article/5ea44cb843274427b98da44986fe76d6
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4ff05e79a58f49b980db63215fe0a4b3
Autor:
Matthew Winter, Rob Coleman, Jessica Kendall, Carlo Palmieri, Chris Twelves, Sacha Howell, Iain MacPherson, Caroline Wilson, Kash Purohit, Jacqui Gath, Christine Taylor, Richard Eastell, Geraldine Murden, Sarah R. Brown, Emma Rathbone, Janet Brown
Publikováno v:
Journal of Bone Oncology, Vol 35, Iss , Pp 100442- (2022)
Background: Approximately 70% of patients with metastatic breast cancer (MBC) develop bone metastases. Despite advances in systemic treatment options and the use of bone targeted agents in the management of bone metastases to reduce skeletal morbidit
Externí odkaz:
https://doaj.org/article/f4c9910e2ee343c2970db1a4f3955768
Autor:
Narendra Nath Basu, James Hodson, Shaunak Chatterjee, Ashu Gandhi, Julie Wisely, James Harvey, Lyndsey Highton, John Murphy, Nicola Barnes, Richard Johnson, Lester Barr, Cliona C. Kirwan, Sacha Howell, Andrew D. Baildam, Anthony Howell, D. Gareth Evans
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Contralateral risk-reducing mastectomy (CRRM) rates have tripled over the last 2 decades. Reasons for this are multi-factorial, with those harbouring a pathogenic variant in the BRCA1/2 gene having the greatest survival benefit. On May 14th,
Externí odkaz:
https://doaj.org/article/5688cd59f9bd429381b2e9941fc6d5dd
Autor:
Rob Coleman, Janet Brown, Emma Rathbone, Louise Flanagan, Amber Reid, Jessica Kendall, Sacha Howell, Chris Twelves, Carlo Palmieri, Anjana Anand, Iain MacPherson, Sarah Brown
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background A substantial proportion of breast cancer patients develop metastatic disease, with over 450,000 deaths globally per year. Bone is the most common first site of metastatic disease accounting for 40% of all first recurrence and 70%
Externí odkaz:
https://doaj.org/article/f23455173b0d42049b53d3ddcd09b49b
Autor:
Senthil Damodaran, Nisha Unni, Karthik V. Giridhar, Brooke Daniel, Sacha Howell, Luis Costa, Marta Ferreira, Masashi Shimura, Gareth Tomlinson, Maciej Gil, Nicholas Turner
Publikováno v:
Cancer Research. 82:P1-18
Background: FGFR gene amplifications are found in 18% of breast cancers (BCs), with FGFR1 amplifications occurring in ≈10% of cases, predominantly in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) MBCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b96d37a950e51bb543b6b8f43af974
https://doi.org/10.1158/1538-7445.sabcs21-p1-18-35
https://doi.org/10.1158/1538-7445.sabcs21-p1-18-35
Autor:
Sacha Howell, Alice Greenhalgh, Robert Pedley, Suad Alghamdi, Amanda Caruso, Mujtaba Ansari, Tiago Moreira, Sue Astlet, Anthony Maxwell, Yit Lim, Hayley Brookes, Faiza Idries, Anthony Howell, D Gareth Evans, Michael Sherratt, Andrew Gilmore, Elaine Harkness, Walid Khaled, Alecia-Jane Twigger, Matt Roberts, Robert Clarke, Bruno Simoes
Publikováno v:
Cancer Research. 82:P1-10
Background The luminal progenitor (LP) population in the normal breast is under the control of paracrine progesterone signalling and likely represents the cell of origin of estrogen receptor negative (ER-) BC. Exogenous progestins, as contraception o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069dfec36e0b755c9b53c8f9321fc204
https://doi.org/10.1158/1538-7445.sabcs21-p1-10-01
https://doi.org/10.1158/1538-7445.sabcs21-p1-10-01