Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

Autor: Matthew D. Lycas, Pia Weikop, Mattias Rickhag, Gitta Wörtwein, Raul R. Gainetdinov, Gunnar Sørensen, Damiana Leo, Jamila H. Lilja, Pedro Rifes, Pernille Herrstedt Ridderstrøm, Ulrik Gether, Freja Herborg, Anders Fink-Jensen, David P.D. Woldbye

Publikováno v: Sørensen, G, Rickhag, M, Leo, D, Lycas, M D, Ridderstrøm, P H, Weikop, P, Lilja, J H, Rifes, P, Herborg, F, Woldbye, D, Wörtwein, G, Gainetdinov, R R, Fink-Jensen, A & Gether, U 2021, ' Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation ', Journal of Biological Chemistry, vol. 297, no. 6, 101361 . https://doi.org/10.1016/j.jbc.2021.101361
The Journal of Biological Chemistry

The dopamine transporter (DAT) is part of a presynaptic multi-protein network involving interactions with scaffold proteins via its C-terminal PDZ-domain binding sequence. Using a mouse model expressing DAT with mutated PDZ binding sequence (DAT-AAA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80451722f31d9f39c558cfd764ce7d5
https://doi.org/10.1016/j.jbc.2021.101361

Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement.

Autor: Pan Z; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Chen J; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Xiao X; Jecho Laboratories, Inc., Frederick, MD 21704, USA.; Jecho Biopharmaceuticals Co., Ltd., Tianjin 300467, China., Xie Y; Jecho Laboratories, Inc., Frederick, MD 21704, USA., Jiang H; Jecho Laboratories, Inc., Frederick, MD 21704, USA.; Jecho Biopharmaceuticals Co., Ltd., Tianjin 300467, China., Zhang B; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Lu H; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Yuan Y; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Han L; Jecho Biopharmaceuticals Co., Ltd., Tianjin 300467, China., Zhou Y; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Zong H; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Wang L; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Sun R; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China., Zhu J; Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; Jecho Laboratories, Inc., Frederick, MD 21704, USA.; Jecho Biopharmaceuticals Co., Ltd., Tianjin 300467, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 Apr; Vol. 12 (4), pp. 1928-1942. Date of Electronic Publication: 2021 Nov 03.

Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.

Autor: Domingos-Pereira S; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland., Hojeij R; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland., Reggi E; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland., Derré L; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland., Chevalier MF; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland., Romero P; Ludwig Center for Cancer Research of University of Lausanne ; Lausanne, Switzerland., Jichlinski P; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland., Nardelli-Haefliger D; Dept. Urology; Lausanne University Hospital (CHUV); Lausanne, Switzerland.

Publikováno v: Oncoimmunology [Oncoimmunology] 2015 May 22; Vol. 4 (7), pp. e1016697. Date of Electronic Publication: 2015 May 22 (Print Publication: 2015).

MC32 tumor cells acquire Ag-specific CTL resistance through the loss of CEA in a colon cancer model.

Autor: Lee SY; a Department of Plastic and Reconstructive Surgery ; School of Medicine; Kangwon National University ; Chuncheon , Gangwon-do , Korea., Sin JI

Publikováno v: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2015; Vol. 11 (8), pp. 2012-20.