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Dissertation/ Thesis

Uniform transgene activation in Tet-On systems depends on sustained rtTA expression

Autor: Otomo, Jun

甲第25201号
医科博第157号
新制||医科||10(附属図書館)
学位規則第4条第1項該当
Doctor of Agricultural Science
Kyoto University
DFAM

Externí odkaz: http://hdl.handle.net/2433/288635

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Akademický článek

Development of a Unique System for Spatiotemporal and Lineage-Specific Gene Expression in Mice

Autor: Yu, Hsiao-Man Ivy, Liu, Bo, Chiu, Shang-Yi, Costantini, Frank, Hsu, Wei, Anderson, Kathryn V.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2005 Jun . 102(24), 8615-8620.

Externí odkaz: https://www.jstor.org/stable/3375761

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Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution

Autor: Xueying Tian, Bin Zhou

Publikováno v: The Journal of Biological Chemistry

Site-specific recombinases (SSRs) are invaluable genome engineering tools that have enormously boosted our understanding of gene functions and cell lineage relationships in developmental biology, stem cell biology, regenerative medicine, and multiple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd835550bfb4c5ce331da13d1125a3f
http://europepmc.org/articles/PMC8050033

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Akademický článek

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Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice

Autor: Ann-Hwee Lee, Curtis J. Bare, Christopher Steven Krumm, Xu Xu, Corey D. Holman, Sander Kersten, Lukas E. Dow, David E. Cohen

Publikováno v: Journal of Biological Chemistry, 297(1)
The Journal of Biological Chemistry
Journal of Biological Chemistry 297 (2021) 1

Cyclic AMP-responsive element-binding protein H (CREBH encoded by Creb3l3) is a transcription factor that regulates the expression of genes that control lipid and glucose metabolism as well as inflammation. CREBH is upregulated in the liver under con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726351a08cf189c64d34823979d8db27
https://research.wur.nl/en/publications/inducible-hepatic-expression-of-crebh-mitigates-diet-induced-obes

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Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice

Autor: Jia Zhang, Klaus H. Kaestner, Kristy Ou, Zhao V. Wang, Phillipp Scherer, Yang Jiao

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 11, Iss, Pp 212-217 (2018)

Objective Both Type I and Type II diabetes mellitus result from insufficient functional β-cell mass. Efforts to increase β-cell proliferation as a means to restore β-cell mass have been met with limited success. Suppression of Tumorigenicity 5 (ST

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cb32edef3707abead555b72e794c88
http://europepmc.org/articles/PMC6001393

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A bestiary of genetic mouse lines and related tools for inducible and reversible intersectional misexpression

Autor: Aditi Singh, Daniel Stephen, Alberto Roselló-Díez, Alexandra L. Joyner, Elham Ahmadzadeh, Xinli Qu, Nermin Sumru Bayin, Linda Madisen, Hongkui Zeng

Publikováno v: Development

Thanks to many advances in genetic manipulation, mouse models have become very powerful in their ability to interrogate biological processes. In order to precisely target expression of a gene of interest to particular cell types, intersectional genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8464c567deb763915dd3b05254930e03

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Tet-On Systems For Doxycycline-inducible Gene Expression

Autor: Liliane Tenenbaum, Ben Berkhout, Atze T. Das

Publikováno v: Current Gene Therapy
Current gene therapy, 16(3), 156-167. Bentham Science Publishers B.V.
Europe PubMed Central

The tetracycline-controlled Tet-Off and Tet-On gene expression systems are used to regulate the activity of genes in eukaryotic cells in diverse settings, varying from basic biological research to biotechnology and gene therapy applications. These sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48daa44899e1e675e433275b5992f1ff
http://europepmc.org/articles/PMC5070417

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Akademický článek

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