Human genetic diversity regulating the TLR10/TLR1/TLR6 locus confers increased cytokines in response to Chlamydia trachomatis

Autor: Alyson B. Barnes, Rachel M. Keener, Benjamin H. Schott, Liuyang Wang, Raphael H. Valdivia, Dennis C. Ko

Publikováno v: HGG Advances, Vol 3, Iss 1, Pp 100071- (2022)

Summary: Human genetic diversity can have profound effects on health outcomes upon exposure to infectious agents. For infections with Chlamydia trachomatis (C. trachomatis), the wide range of genital and ocular disease manifestations are likely influ

Externí odkaz: https://doaj.org/article/7f6bbf7c88c345af81126b7eeed8e51c

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

Autor: Ephraim L. Tsalik, Alejandro L. Antonia, Liuyang Wang, Micah T. McClain, Elizabeth R. Hauser, Thomas J Balmat, Mark R. DeLong, Thomas W. Burke, Xiling Shen, Andy Ingham, Emily R Ko, Dennis C. Ko, Christopher W. Woods, Florica J Constantine, Geoffrey S. Ginsburg, Ricardo Henao

Publikováno v: medRxiv
article-version (status) pre
article-version (number) 1
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-19 (2021)

Background While genome-wide associations studies (GWAS) have successfully elucidated the genetic architecture of complex human traits and diseases, understanding mechanisms that lead from genetic variation to pathophysiology remains an important cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746fc7b1a6c15759a266e26aadcaf580
https://doi.org/10.1101/2020.12.20.20248572

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An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.

Autor: Wang L; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Balmat TJ; Duke Research Computing, Duke University, Durham, NC 27710, USA., Antonia AL; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Constantine FJ; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Henao R; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Burke TW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Ingham A; Duke Research Computing, Duke University, Durham, NC 27710, USA., McClain MT; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.; Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Tsalik EL; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.; Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Ko ER; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Department of Hospital Medicine, Duke Regional Hospital, Durham, NC, 27705, USA., Ginsburg GS; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., DeLong MR; Duke Research Computing, Duke University, Durham, NC 27710, USA., Shen X; Department of Biomedical Engineering, Woo Center for Big Data and Precision Health, Duke University, Durham, NC 27710, USA., Woods CW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.; Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Hauser ER; Duke Molecular Physiology Institute and Department of Biostatistics and Bioinformatics, Duke University Medical Center Durham, NC 27710, USA.; Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC 27705, USA., Ko DC; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Lead contact.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2020 Dec 22. Date of Electronic Publication: 2020 Dec 22.