Zobrazeno 1 - 10
of 174
pro vyhledávání: '"root mean square fluctuation"'
Autor:
Sharma Kirti, Sharma Atul, Sanduja Mohit, Jogpal Vikas, Mishra Asim Kumar, Kumar Girish, Virmani Tarun, Noman Omar M., Alhalmi Abdulsalam
Publikováno v:
Open Chemistry, Vol 22, Iss 1, Pp 57-72 (2024)
The rising instances of drug resistance in Mycobacterium tuberculosis strains pose a significant global health challenge. Conventional tuberculosis (TB) treatments, which typically involve multiple antibiotics, face hurdles like drug resistance, redu
Externí odkaz:
https://doaj.org/article/6bb3ba9137e14de8a26026a6b01900fa
Akademický článek
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Publikováno v:
مجله انفورماتیک سلامت و زیست پزشکی, Vol 8, Iss 1, Pp 105-116 (2021)
Introduction: P53 is a tumor suppressor protein with numerous missense mutations identified in its gene. These mutations are observed in a vast number of cancers. R213G is one of them which has a role in metastatic lung cancers. In this research, R21
Externí odkaz:
https://doaj.org/article/44827ec1fbb04792b1acdadbfb53cec2
Autor:
Satyamvada Maurya, Amita Jain, Md Tabish Rehman, Ali Hakamy, Farkad Bantun, Mohamed F. AlAjmi, Vineeta Singh, Aafreen Zehra, Feroz Khan, Shafiul Haque, Bhartendu Nath Mishra
Publikováno v:
Molecules, Vol 28, Iss 4, p 1652 (2023)
The emergence of multi-drug-resistant Mycobacterium tuberculosis (Mtb) strains has rendered many of the currently available anti-TB drugs ineffective. Hence, there is a pressing need to discover new potential drug targets/candidates. In this study, a
Externí odkaz:
https://doaj.org/article/ce56bd3bac0d4518a6ff889b4748a5cf
Akademický článek
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Publikováno v:
Open Chemistry, Vol 14, Iss 1, Pp 188-196 (2016)
A molecular dynamics (MD) simulation study of the enzymatic portion of cholera toxin; cholera toxin A-1 polypeptide (CTA1) was performed at 283, 310 and 323 K. From total energy analysis it was observed that this toxin is stable thermodynamically and
Externí odkaz:
https://doaj.org/article/fcab7c37a5fb466e8dfbb07a36ebd980
Autor:
Max Luedemann, Daniela Stadler, Cho-Chin Cheng, Ulrike Protzer, Percy A. Knolle, Sainitin Donakonda
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 799-811 (2022)
Computational and Structural Biotechnology Journal
Comp. Struc. Biotech. J. 20, 799-811 (2022)
Computational and Structural Biotechnology Journal
Comp. Struc. Biotech. J. 20, 799-811 (2022)
Graphical abstract
Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of S
Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf39d53fae30a82c808044069a25f50d
http://www.sciencedirect.com/science/article/pii/S2001037022000319
http://www.sciencedirect.com/science/article/pii/S2001037022000319
Autor:
Zulkar Nain, Mohaimenul Islam Tareq, Abdullah-Al-Mamun, Suza Mohammad Nur, Thamer A. Bouback, Raihan Rahman Imon, Ishtiaq Qadri, Shahedur Rahman, Foysal Ahammad, Saddam Hossen, Rahat Alam, Tomasz M. Karpiński, Abdus Samad, Enamul Kabir Talukder, Sushil Pokhrel
Publikováno v:
International Journal of Biological Macromolecules
Angiotensin-converting enzyme 2 (ACE2), also known as peptidyl-dipeptidase A, belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral drug target against SARS-CoV-2. Most of the ACE2 inhibitors discovered till now ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e497649ef3b10bf02881728e8cfa000
https://doi.org/10.1016/j.ijbiomac.2021.09.146
https://doi.org/10.1016/j.ijbiomac.2021.09.146
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b197d7e1bd61447a9d7a45da0a56387
https://doi.org/10.1016/j.apsb.2021.03.011
https://doi.org/10.1016/j.apsb.2021.03.011
Autor:
Mohd Imran Khan, Taehwan Park, Abd El Aziem Farouk, Saqer S. Alotaibi, Jae June Dong, Mohammad Hassan Baig
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3262-3269 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
SARS-CoV-2, previously named 2019 novel coronavirus (2019-nCoV), has been associated with the global pandemic of acute respiratory distress syndrome. First reported in December 2019 in the Wuhan province of China, this new RNA virus has several folds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac475456e9d058c0a72cdc720d4a9da
http://www.sciencedirect.com/science/article/pii/S1319562X21001388
http://www.sciencedirect.com/science/article/pii/S1319562X21001388