A gain-of-function mutation in zinc cluster transcription factor Rob1 drives Candida albicans adaptive growth in the cystic fibrosis lung environment.

Autor: Mayssa Gnaien, Corinne Maufrais, Yasmine Rebai, Aicha Kallel, Laurence Ma, Samia Hamouda, Fatma Khalsi, Khaoula Meftah, Hanen Smaoui, Monia Khemiri, Sondes Hadj Fredj, Sophie Bachellier-Bassi, Imène Najjar, Taieb Messaoud, Khadija Boussetta, Kalthoum Kallel, Helmi Mardassi, Christophe d'Enfert, Marie-Elisabeth Bougnoux, Sadri Znaidi

Publikováno v: PLoS Pathogens, Vol 20, Iss 4, p e1012154 (2024)

Candida albicans chronically colonizes the respiratory tract of patients with Cystic Fibrosis (CF). It competes with CF-associated pathogens (e.g. Pseudomonas aeruginosa) and contributes to disease severity. We hypothesize that C. albicans undergoes

Externí odkaz: https://doaj.org/article/3f782e6103b6485eb5a0f45c57ed332f

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and oral commensalism

Autor: Virginia E. Glazier, Juraj Kramara, Tomye Ollinger, Norma V. Solis, Robert Zarnowski, Rohan S. Wakade, Min-Ju Kim, Gabriel J. Weigel, Shen-Huan Liang, Richard J. Bennett, Melanie Wellington, David R. Andes, Mark A. Stamnes, Scott G. Filler, Damian J. Krysan

Publikováno v: mBio, Vol 14, Iss 5 (2023)

ABSTRACT Candida albicans is a diploid human fungal pathogen that displays significant genomic and phenotypic heterogeneity over a range of virulence traits and in the context of a variety of environmental niches. Here, we show that the effect of Rob

Externí odkaz: https://doaj.org/article/d9d88ba2cedc4442aa5ec5ea0648059b

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral commensalism.

Autor: Glazier VE; Department of Biology, Niagara University, Niagara Falls NY., Kramara J; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City IA., Ollinger T; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City IA., Solis NV; Division of Infectious Diseases, Los Angeles Biomedical Research Institute and Harbor-UCLA Medical Center, Torrance, CA.; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA., Zarnowski R; Department of Medicine, Section of Infectious Disease, University of Wisconsin, Madison WI.; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison WI., Wakade RS; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City IA., Kim MJ; Department of Microbiology, University of Georgia, Athens, GA., Weigel GJ; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City IA., Liang SH; Department of Molecular Microbiology and Immunology, Brown University, Providence, RI., Bennett RJ; Department of Molecular Microbiology and Immunology, Brown University, Providence, RI., Wellington M; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City IA., Andes DR; Department of Medicine, Section of Infectious Disease, University of Wisconsin, Madison WI.; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison WI., Stamnes MA; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA., Filler SG; Division of Infectious Diseases, Los Angeles Biomedical Research Institute and Harbor-UCLA Medical Center, Torrance, CA.; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA., Krysan DJ; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City IA.; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA.; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City IA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 17. Date of Electronic Publication: 2023 Jun 17.

Descondensación de la heterocromatina en bovinos criollos portadores de la translocación Robertsoniana (rob1; 29). Acción del inductor 5-azacitidina-C Heterochromatin decondesation in Creole cattle carrier of Robertsonian franslocation (rob 1; 29). Action of 5-azacytidine-C

Autor: Rody Artigas, Wanda Iriarte, Leticia de Soto, Andrés Iriarte, Silvia Llambí, Miguel de Bethencourt, Alicia Postiglioni

Publikováno v: Acta Agronómica, Vol 57, Iss 1, Pp 65-69 (2008)

La translocación Robertsoniana (rob1; 29) está ampliamente distribuida en razas comerciales y en reservas genéticas de bovinos Criollos americanos. Se ha descrito un enlentecimiento en el desarrollo de embriones portadores de esta aneuploidía, fr

Externí odkaz: https://doaj.org/article/5cbfb4aaff614360a8e8bcc40aa90d4a

Effects of the orange lemma (rob1) mutant line of barley cv. ‘Optic’ compared with its wild-type on the ruminal microbiome and fermentation tested with the rumen simulation technique

Autor: Qendrim Zebeli, Renee M. Petri, C. Emsenhuber, Fenja Klevenhusen, Heinrich Grausgruber

Publikováno v: Crop and Pasture Science. 70:789

The use of cereals as forage crops is limited due to the high lignin content in the cell walls reducing nutrient digestibility. Recent research has focused on reducing lignification in forage crops through gene mutations. This study investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e38baf446c3599bdef80fc0e4eb55764
https://doi.org/10.1071/cp18288