Zobrazeno 1 - 10
of 101
pro vyhledávání: '"rna sensor"'
Autor:
Masaki Okamoto, Yoshiaki Zaizen, Shinjiro Kaieda, Takashi Nouno, Takuma Koga, Goushi Matama, Masahiro Mitsuoka, Jun Akiba, Shintaro Yamada, Hiroki Kato, Tomoaki Hoshino
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31727- (2024)
Viral double-stranded RNA (dsRNA) is sensed by toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including melanoma differentiation-associated gene 5 (MDA5). MDA5 recognizes the genome of dsRNA viruses and
Externí odkaz:
https://doaj.org/article/8b8478b759654b2a8704924d6b1052e2
Autor:
Qian Hou, Samie R. Jaffrey
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 198-206 (2023)
RNA aptamers are structured RNAs that can bind to diverse ligands, including proteins, metabolites, and other small molecules. RNA aptamers are widely used as in vitro affinity reagents. However, RNA aptamers have not been highly successful as bioact
Externí odkaz:
https://doaj.org/article/12a5e1b8b2a94a93b8388256b536cc86
Publikováno v:
Biosensors and Bioelectronics: X, Vol 16, Iss , Pp 100438- (2024)
Herein, we report a carbon-stabilized porous silicon (pSi)-based electrochemical biosensing platform for the label- and amplification-free detection of bacterial 16S rRNA gene fragments that facilitates pan-bacterial detection. The sensing approach c
Externí odkaz:
https://doaj.org/article/9b7289a3e48f430d8b4645a1c2a6c3c5
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract RNA sensors detect foreign and endogenous RNAs to protect the host by initiating innate and adaptive immune response. In tumor microenvironment (TME), activation of RNA sensors induces tumor-inhibitory cytotoxic T lymphocyte responses and in
Externí odkaz:
https://doaj.org/article/5a94ad6d3f004e5e8d14e92543763556
Autor:
Enrique Martin-Gayo, Ce Gao, Marta Calvet-Mirabent, Zhengyu Ouyang, Mathias Lichterfeld, Xu G. Yu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionSpontaneous control of HIV-1 replication in the absence of anti-retroviral therapy (ART) naturally occurs in a small proportion of HIV-1-infected individuals known as elite controllers (EC), likely as a result of improved innate and adapt
Externí odkaz:
https://doaj.org/article/d0993bba3c584d35905b779477dfc941
Autor:
Siji Li, Lili Cao, Zeming Zhang, Ming Kuang, Luoying Chen, Yingchi Zhao, Yujie Luo, Zhinan Yin, Fuping You
Publikováno v:
Molecular Biomedicine, Vol 2, Iss 1, Pp 1-12 (2021)
Abstract The innate immune system is the first line of host defense, which responds rapidly to viral infection. Innate recognition of viruses is mediated by a set of pattern recognition receptors (PRRs) that sense viral genomic nucleic acids and/or r
Externí odkaz:
https://doaj.org/article/3a39a3679bf74432894e4ae64cddd0e5
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
In vitro transcribed (IVT) synthetic mRNAs are in high demand due to their attractive bench to clinic translational processes. Mainly, the procedure to make IVT mRNA using bacteriophage RNA polymerases (RNAP) is relatively uncomplicated and scalable
Externí odkaz:
https://doaj.org/article/83c05d1bbfb945cc82e16fbe43447858
Akademický článek
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Akademický článek
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Publikováno v:
Cells, Vol 12, Iss 12, p 1650 (2023)
Kaposi’s sarcoma-associated herpesvirus (KSHV) and the Epstein–Barr virus (EBV) are double-stranded DNA oncogenic gammaherpesviruses. These two viruses are associated with multiple human malignancies, including both B and T cell lymphomas, as wel
Externí odkaz:
https://doaj.org/article/4b7ce7958b204c0daae71f9f2a4a8d93