Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation

Autor: Qi Zhao, Lorenzo Pavanello, Mark Bartlam, Gerlof Sebastiaan Winkler

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

In eukaryotic cells, the synthesis, processing, and degradation of mRNA are important processes required for the accurate execution of gene expression programmes. Fully processed cytoplasmic mRNA is characterised by the presence of a 5′cap structur

Externí odkaz: https://doaj.org/article/aaa00c34c6474f86bc96b7953a49fef9

The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis

Autor: Nai-Wen Chang, Yi-Ping Huang

Publikováno v: BioMedicine, Vol 9, Iss 4, p 27 (2019)
BioMedicine

Background: The activation of peroxisome proliferator-activated receptor alpha (PPARα) has been shown to reprogram tumor metabolism and exhibits great potential for treating anti-oral tumorigenesis. Methods: In this study, we used a pathway-based st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056a095b95a91c4f4efd54f4115eee62
https://biomedicine.edp-open.org/articles/bmdcn/full_html/2019/04/bmdcn2019090427/bmdcn2019090427.html

In vitro characterization of Nudt16 orthologs by sequence and function provide evidence supporting a nuclear RNA degradation pathway

Autor: Melissa J. Taylor-Holou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abfc4e27d1c0f02b8962068a4d412eff
https://doi.org/10.32469/10355/9560

Nonsense-mediated mRNA decay:an intricate machinery that shapes transcriptomes

Autor: Søren Lykke-Andersen, Torben Heick Jensen

Publikováno v: Lykke-Andersen, S & Jensen, T H 2015, ' Nonsense-mediated mRNA decay : an intricate machinery that shapes transcriptomes ', Nature Reviews. Molecular Cell Biology, vol. 16, pp. 665-677 . https://doi.org/10.1038/nrm4063

Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39c649578b49d8799bb94fd9561a81f
https://pure.au.dk/portal/da/publications/nonsensemediated-mrna-decay(b71ffa9e-0fcb-49f8-8821-8eb4e0ffbc25).html