Design, Synthesis and Characterization of [G10a]-Temporin SHa Dendrimers as Dual Inhibitors of Cancer and Pathogenic Microbes

Autor: Arif Iftikhar Khan, Shahzad Nazir, Aaqib Ullah, Muhammad Nadeem ul Haque, Rukesh Maharjan, Shabana U. Simjee, Hamza Olleik, Elise Courvoisier-Dezord, Marc Maresca, Farzana Shaheen

Publikováno v: Biomolecules, Vol 12, Iss 6, p 770 (2022)

As the technologies for peptide synthesis and development continue to mature, antimicrobial peptides (AMPs) are being widely studied as significant contributors in medicinal chemistry research. Furthermore, the advancement in the synthesis of dendrim

Externí odkaz: https://doaj.org/article/7b7b6df3f9a4449aaafe41c9444378ad

Investigation of On-Resin Disulfide Formation for Large-Scale Manufacturing of Cyclic Peptides: A Case Study

Autor: Lena Hansen, Yi Yang, Fabrizio Badalassi

Publikováno v: Organic Process Research & Development. 24:1281-1293

Peptide molecules bearing disulfide moieties constitute an important category of therapeutics. The establishment of the disulfide structure plays a pivotal role in the production of those peptides....

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2dc4b0c3159548276857c51428d8673
https://doi.org/10.1021/acs.oprd.0c00168

Fragment synthesis of disulfide-containing peptides

Autor: Yuxuan Dai, Hai Qian, Na Yue, Wenlong Huang

Publikováno v: MethodsX
MethodsX, Vol 7, Iss, Pp 100945-(2020)

A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb1ff1241ea4ce239cbdb15e613239f
http://europepmc.org/articles/PMC7303597

Furan-Conjugated Tripeptides as Potent Antitumor Drugs

Autor: Goudard, Nicolas, Ajandouz, El, Berdah, Stéphane, Moutardier, Vincent, BEGE, Thierry, BIRNBAUM, David, Perrier, Josette, Di Pasquale, Eric, Maresca, Marc, Ali, Hunain, Jabeen, Almas, Maharjan, Rukesh, Nadeem-ul-Haque, Muhammad, Aamra, Husena, Nazir, Salma, Khan, Serab, Olleik, Hamza, Shaheen, Farzana, Rhayat, Lamya, Nicoletti, Cendrine, Brinch, Karoline Sidelmann, Christian, Sonja, Devillard, Estelle, Eckhardt, Erik

Publikováno v: Biomolecules, Vol 10, Iss 1684, p 1684 (2020)
Biomolecules
Biomolecules, MDPI, 2020, 10 (12), pp.1684. ⟨10.3390/biom10121684⟩
Biomolecules, 2020, 10 (12), pp.1684. ⟨10.3390/biom10121684⟩
Volume 10
Issue 12

Cervical cancer is among the leading causes of death in women. Chemotherapy options available for cervical cancer include highly cytotoxic drugs such as taxol, cisplatin, 5-florouracil, and doxorubicin, which are not specific. In the current study, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f8e43ca63fb2309842aea48d042d68
https://doi.org/10.3390/biom10121684

Efficient synthesis of CN2097 using in situ activation of sulfhydryl group

Autor: Dennis J. Goebel, Shaban Darwish, Rakesh Tiwari, John Marshall, Keykavous Parang

Publikováno v: Tetrahedron letters. 58(31)

CN2097 (R7Cs-sCYK[KTE(β-Ala)]V) is a rationally designed peptidomimetic that shows effectiveness in preclinical models for the treatment of neurological disorders, such as Angelman syndrome, traumatic brain injury (TBI) and stroke. Because of its th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8f7811d51a5f652fcc03fe19305478
https://pubmed.ncbi.nlm.nih.gov/28824209