Zobrazeno 1 - 10
of 9 024
pro vyhledávání: '"rig-i"'
Autor:
Yuxin Yang, XianWang Hu, Shuangshuang Wang, Yongxiang Tian, Keli Yang, Chang Li, Qiong Wu, Wei Liu, Ting Gao, Fangyan Yuan, Rui Guo, Zewen Liu, Yuying Yang, Danna Zhou
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-11 (2024)
Abstract Background Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic pathogen that causes encephalitis in humans and reproductive failure in pigs. The transmission of JEV between humans and animals poses a significant public health thre
Externí odkaz:
https://doaj.org/article/26b96bb9fa43436db7a88ba3944448df
Autor:
Haoyuan Xu, Wanpeng Li, Kai Xue, Huankang Zhang, Han Li, Haoran Yu, Li Hu, Yurong Gu, Houyong Li, Xicai Sun, Quan Liu, Dehui Wang
Publikováno v:
Non-coding RNA Research, Vol 10, Iss , Pp 116-129 (2025)
Following the initial treatment of nasopharyngeal carcinoma (NPC), tumor progression often portends an adverse prognosis for these patients. MicroRNAs (miRNAs) have emerged as critical regulators of tumor immunity, yet their intricate mechanisms in N
Externí odkaz:
https://doaj.org/article/6e4ad05cc60249c48764063af605d6ab
Autor:
Xiaobing Duan, Jiali Hu, Yuncong Zhang, Xiaoguang Zhao, Mingqi Yang, Taoping Sun, Siya Liu, Xin Chen, Juan Feng, Wenting Li, Ze Yang, Yitian Zhang, Xiaowen Lin, Dingjie Liu, Ya Meng, Guang Yang, Qiuping Lin, Guihai Zhang, Haihong Lei, Zhengsheng Yi, Yanyan Liu, Xiaobing Liang, Yujuan Wu, Wenqing Diao, Zesong Li, Haihai Liang, Meixiao Zhan, Hong-Wei Sun, Xian-Yang Li, Ligong Lu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 3005-3025 (2024)
Abstract Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor involved in innate immunity, but its role in adaptive immunity, specifically in the context of CD8+ T-cell antitumour immunity, remains unclear. Here, we demonstrate th
Externí odkaz:
https://doaj.org/article/59d8b008363244d1ad0a57728bdc6b90
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-11 (2024)
Abstract Senecavirus A (SVA) is an emerging virus that poses a threat to swine herds worldwide. To date, the role of tripartite motif 5 (TRIM5) in the replication of viruses has not been evaluated. Here, TRIM5 was reported to inhibit SVA replication
Externí odkaz:
https://doaj.org/article/db0d41db3382421c89cf4b677b464b8c
Publikováno v:
Guangdong nongye kexue, Vol 51, Iss 7, Pp 151-160 (2024)
【Objective】Tembusu virus (TMUV) disease is an important infectious disease in waterfowl. In previous studies, we found that in the early stages of TMUV infection in ducks, the viral copy number of group 2 TMUV in organs such as the liver, kidney,
Externí odkaz:
https://doaj.org/article/d606c75e1f364346a76b617122c9f746
Autor:
Jiyu Zhang, Liaoyuan Zhang, Dakai Liu, Hongyan Shi, Xin Zhang, Jianfei Chen, Xiaoman Yang, Miaomiao Zeng, Jialin Zhang, Tingshuai Feng, Xiaoyuan Zhu, Zhaoyang Jing, Zhaoyang Ji, Da Shi, Li Feng
Publikováno v:
mBio, Vol 15, Iss 12 (2024)
ABSTRACT Type Ι interferon (IFN) production mediated by retinoic acid-inducible gene 1 (RIG-I) and mitochondrial antiviral signaling protein (MAVS) is essential for antiviral innate immune responses. Here, we report the identification of a novel co-
Externí odkaz:
https://doaj.org/article/59d110772ddb4ab8a965bfa598779162
RIG012 assists in the treatment of pneumonia by inhibiting the RIG-I-like receptor signaling pathway
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectivePneumonia is a common clinical condition primarily treated with antibiotics and organ support. Exploring the pathogenesis to identify therapeutic targets may aid in the adjunct treatment of pneumonia and improve survival rates.MethodsTranscr
Externí odkaz:
https://doaj.org/article/d2db20c6d4254e7fb110ec3f83d683f1
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Current cancer therapies often fall short in addressing the complexities of malignancies, underscoring the urgent need for innovative treatment strategies. RNA interference technology, which specifically suppresses gene expression
Externí odkaz:
https://doaj.org/article/c7b511a39ae440e0895e9700fee56886
Autor:
Jiyu Zhang, Hongyan Shi, Liaoyuan Zhang, Tingshuai Feng, Jianfei Chen, Xin Zhang, Zhaoyang Ji, Zhaoyang Jing, Xiaoyuan Zhu, Dakai Liu, Xiaoman Yang, Miaomiao Zeng, Da Shi, Li Feng
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-14 (2024)
Abstract Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging Alpha-coronavirus, brings huge economic loss in swine industry. Interferons (IFNs) participate in a frontline antiviral defense mechanism triggering the activation of numerous
Externí odkaz:
https://doaj.org/article/77aab75867b14a959000fcb5363ff15a
Autor:
Tinghui Huang, Xudong Ao, Jie Liu, Chuancheng Sun, Yunfei Dong, Xuechen Yin, Yan Zhang, Xinping Wang, Wenying Li, Jiujiu Cao, Feiyan Pan, Zhigang Hu, Zhigang Guo, Lingfeng He
Publikováno v:
Translational Oncology, Vol 51, Iss , Pp 102230- (2025)
Our experimental study showed that METTL3 was highly expressed in NSCLC cells and promoted the growth of tumor cells. METTL3 takes N6-methyladenosine (m6A) as the main means of mRNA modification to control the expression and function of RIG-I-MAVS si
Externí odkaz:
https://doaj.org/article/6e2a23b1017742e1ad5b2a37310d080f