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Akademický článek

Identification and expression of microRNA-34a-3p and its target Rapamycin-insensitive companion of mTOR (RICTOR) in polycystic ovarian syndrome in South Indian population

Autor: Saravanan Manya, P Ameya K, P Ashikha Shirin Usman P, Sekar Durairaj

Publikováno v: Acta Marisiensis - Seria Medica, Vol 70, Iss 3, Pp 163-168 (2024)

Polycystic Ovarian Syndrome (PCOS) is a complex condition affecting 4% to 26% of the world-wide population and is characterized by enlarged ovaries and cysts. These cysts are actually immature ovarian follicles that have failed to mature and release

Externí odkaz: https://doaj.org/article/911f475c8f4d410a95e390bb9d9bbdd8

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Akademický článek

Increased mTOR activity and RICTOR copy number in small cell lung carcinoma progression

Autor: Dániel Sztankovics, Fatime Szalai, Dorottya Moldvai, Titanilla Dankó, Noémi Nagy, Judit Pápay, András Khoór, Ildikó Krencz, Anna Sebestyén

Publikováno v: European Journal of Cell Biology, Vol 103, Iss 4, Pp 151468- (2024)

Small cell lung carcinoma (SCLC) is a highly malignant cancer with early metastatic dissemination and poor clinical outcomes. Mutations in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway, i

Externí odkaz: https://doaj.org/article/330b1db415774fd19967c36c4c2a7cae

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Akademický článek

Screening high-risk individuals for primary gastric adenocarcinoma: evaluating progression-free survival probability score in the presence and absence of Rictor expression after gastrectomy

Autor: Jian Wang, Yifan Li, Sujiao Liang

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

ObjectiveDeveloping nomogram-based risk stratification model to determine 3-year and 5-year progression-free survival (PFS) and to identify high-risk patients with gastric adenocarcinoma based on different Rictor statuses.Methods1366 individuals who

Externí odkaz: https://doaj.org/article/e3a09289a0994f668fdfd74be17f8a25

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Akademický článek

RICTOR/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)

Abstract Background The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to assess in this context the

Externí odkaz: https://doaj.org/article/18874da7221f495c92ee85e23df7d535

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Akademický článek

RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis

Autor: Xu, Jingting ^{a, 1}, Wang, Genchun ^{a, b, 1}, Hou, Yanjun ^a, Sun, Kai ^a, Zheng, Zehang ^a, Guo, Zhou ^a, Hou, Liangcai ^a, Zhang, Xiong ^a, Ruan, Zhaoxuan ^a, Ye, Yaping ^{a, ⁎}, Guo, Fengjing ^{a, ⁎}

Publikováno v: In International Immunopharmacology 10 January 2025 144

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Akademický článek

RICTOR amplification is associated with Rictor membrane staining and does not correlate with PD-L1 expression in lung squamous cell carcinoma

Autor: Ildikó Krencz, Dániel Sztankovics, Anna Sebestyén, Judit Pápay, Titanilla Dankó, Dorottya Moldvai, Elmar Lutz, Andras Khoor

Publikováno v: Pathology and Oncology Research, Vol 30 (2024)

RICTOR gene, which encodes the scaffold protein of mTORC2, can be amplified in various tumor types, including squamous cell carcinoma (SCC) of the lung. RICTOR amplification can lead to hyperactivation of mTORC2 and may serve as a targetable genetic

Externí odkaz: https://doaj.org/article/fc3d684fdaff4c96b26aca54c6f8cf21

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Akademický článek

mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies

Autor: Dániel Sztankovics, Dorottya Moldvai, Gábor Petővári, Titanilla Dankó, Fatime Szalai, Risa Miyaura, Viktória Varga, Noémi Nagy, Gergő Papp, Judit Pápay, Ildikó Krencz, Anna Sebestyén

Publikováno v: Pathology and Oncology Research, Vol 30 (2024)

The increasing knowledge of molecular alterations in malignancies, including mutations and regulatory failures in the mTOR (mechanistic target of rapamycin) signaling pathway, highlights the importance of mTOR hyperactivity as a validated target in c

Externí odkaz: https://doaj.org/article/50d1c7653f534df2bad19730c717af5b

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Akademický článek

Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis

Autor: Chun Wang, Hui Kang, Yun Yi, Yang Ding, Fan Wang, Jie Luo, Mingliang Ye, Yinghui Hong, Chao Xia, Junwei Yan, Lan Liu, Jing Liu, Zibiao Zhong, Zhonglin Zhang, Qiu Zhao, Ying Chang

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)

Abstract Background Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10% in cohorts without hepatitis

Externí odkaz: https://doaj.org/article/3bb3f808dc80437c8a24196bb502ccda

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Akademický článek

miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor

Autor: Kang Hui, Luo Jie, Wang Chun, Hong Yinghui, Ye Mingliang, Ding Yang, Zhao Qiu, Chang Ying

Publikováno v: Open Medicine, Vol 18, Iss 1, Pp 245-66 (2023)

The activation of hepatic stellate cells (HSCs) is regarded as the primary driving factor of liver fibrosis. miR-192, a miRNA associated with hepatocellular carcinoma and enriched in HSCs, has an undisclosed role in HSC activation and liver fibrosis.

Externí odkaz: https://doaj.org/article/8bf5600bb28d4e8e8baaa7f5eb6bc403

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Akademický článek

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